急性脑梗死患者血清脂联素、C反应蛋白、基质金属蛋白酶-9、尿酸水平变化及临床意义

发布时间：2018-01-20 16:10

本文关键词： 脂联素 C反应蛋白基质金属蛋白酶- 尿酸急性脑梗死　出处：《中国老年学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的观察急性脑梗死(ACI)患者血清脂联素(ADP)、C反应蛋白(CRP)、基质金属蛋白酶(MMP)-9及尿酸(UA)的水平及意义。方法选择138例ACI患者为ACI组。同时选取95例健康体检者作为健康对照组,ACI组行头颅MRI检查后,根据Pullicino方法计算梗死体积,据结果进一步分为小梗死组、中梗死组和大梗死组,进一步比较三个亚组中血清ADP、CRP、MMP-9、UA水平,对比分析ACI患者血清中上述指标与脑梗死病灶体积的相关性。结果 ACI组CRP、MMP-9和UA水平较对照组明显升高,ADP水平较对照组显著降低(P0.05)。随着脑梗死病灶体积的增大,CRP、MMP-9和UA水平亦逐渐升高,各指标与脑梗死体积呈显著正相关;同时ADP水平与脑梗死病灶体积分级呈显著负相关。结论血清中CRP、MMP-9和UA水平可能与ACI的发病以及疾病的严重程度有关,血清ADP可能为ACI的保护性因子。
[Abstract]:Objective to observe the serum adiponectin (ADP) C-reactive protein (CRP) in patients with acute cerebral infarction (ACI). Methods 138 patients with ACI were selected as ACI group and 95 healthy persons as control group. According to the Pullicino method, the ACI group was further divided into small infarction group, middle infarction group and large infarction group. Furthermore, the serum levels of ADPtCr, MMP-9 and UA in the three subgroups were compared. Results the serum levels of MMP-9 and UA in ACI group were significantly higher than those in control group. The level of ADP was significantly lower than that of the control group (P 0.05). The levels of MMP-9 and UA increased gradually with the increase of the volume of cerebral infarction, and there was a significant positive correlation between each index and the volume of cerebral infarction. At the same time, the level of ADP was negatively correlated with the volume grade of cerebral infarction. Conclusion the levels of MMP-9 and UA in serum may be related to the pathogenesis of ACI and the severity of the disease. Serum ADP may be a protective factor for ACI.
【作者单位】：郑州大学附属郑州中心医院神经内科;
【基金】：河南省医学科技攻关计划项目(No.122300410026)
【分类号】：R743.33
【正文快照】： 脑梗死是由各种原因所致的局部脑组织血液供应障碍,脑组织缺血缺氧进而引起的脑部坏死性病变〔1〕,临床上主要表现为神经功能缺失的表现〔2〕。在我国急性脑梗死(ACI)的发病率和病死率均较高,已然成为国民死亡的首位原因〔3〕。目前ACI的患病率亦迅速上升,给社会和家庭造成了

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