rt-PA与尿激酶溶栓治疗脑血栓的临床效果对比分析

发布时间：2018-01-23 10:46

本文关键词： rt-PA 尿激酶溶栓脑血栓神经功能缺损　出处：《世界最新医学信息文摘》2016年A1期 　论文类型：期刊论文

【摘要】：目的:对比分析脑血栓患者采用重组组织型纤溶酶原激活剂(rt-PA)与尿激酶溶栓治疗的临床效果。方法:选取我院脑血栓患者66例作为研究对象,采用奇偶分组法均分为对照组和观察组,每组各33例。对照组患者采用尿激酶溶栓治疗,观察组患者则采用rt-PA治疗。结果:治疗前和治疗后两组患者NIHSS评分比较无明显差异(P0.05),但治疗后两组患者的NIHSS评分均明显比治疗前低(P0.05);观察组患者并发症发生率较低,与对照组患者相比,差异显著(P0.05);两组患者临床治疗总有效率均较高,组间比较无明显差异(P0.05);治疗后15d、60d观察组患者Barthel积分均明显比对照组高,差异有统计学意义(P0.05)。结论:rt-PA与尿激酶溶栓治疗脑血栓的临床效果均较好,可显著改善患者神经缺损情况,但脑血栓患者采用rt-PA治疗并发症更少,且治疗后患者日常生活能力改善更为显著,与采用尿激酶溶栓治疗相比,具有显著优势,因此值得将rt-PA治疗在临床中推广应用。
[Abstract]:Objective: to compare and analyze the clinical effect of recombinant tissue plasminogen activator (rt-PA) and urokinase in patients with cerebral thrombosis. Methods: 66 patients with cerebral thrombosis in our hospital were selected as study objects. The patients in the control group were divided into control group and observation group with 33 cases in each group. The patients in the control group were treated with urokinase thrombolytic therapy. The patients in the observation group were treated with rt-PA. Results: there was no significant difference in NIHSS score between the two groups before and after treatment (P 0.05). However, the NIHSS scores of the two groups were significantly lower than those before treatment (P 0.05). The incidence of complications in the observation group was lower than that in the control group (P 0.05). The total effective rate of clinical treatment was higher in the two groups, and there was no significant difference between the two groups (P 0.05). The Barthel scores in the observation group were significantly higher than those in the control group 15 days after treatment. The difference was statistically significant (P 0.05). Conclusion the clinical effect of thrombolytic therapy with urokinase and weight rt-PA is better than that with urokinase, which can significantly improve the neurologic defect in patients with cerebral thrombosis. However, patients with cerebral thrombosis treated with rt-PA less complications, and after treatment of patients with improved ability of daily life more significantly, compared with urokinase thrombolytic therapy, has a significant advantage. Therefore, it is worth popularizing rt-PA therapy in clinic.
【作者单位】：江苏省沛县人民医院;
【分类号】：R743.32
【正文快照】： 0引言脑血栓是神经内科常见疾病之一,主要是由于脑内动脉发生粥样硬化所导致的,患者动脉内膜受损,血液粘稠度增高,因此易出现血栓,进而导致血管狭窄,甚至闭塞,并引起一系列继发性病变[1]。脑血栓是急性脑梗死疾病中最典型的一种,常见于中老年群体,该病起病急、病情严重,且进展

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