脑心通胶囊治疗急性脑梗死疗效及对细胞炎症因子、凝血功能和血液流变学的影响

发布时间：2018-01-24 02:18

本文关键词： 脑心通胶囊急性脑梗死疗效细胞炎症因子凝血功能血液流变学　出处：《中华中医药学刊》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨脑心通胶囊治疗急性脑梗死患者疗效及对细胞炎症因子、凝血功能和血液流变学的影响。方法:急性脑梗死患者98例按照随机数字表法分为治疗组49例与对照组49例。对照组患者采用常规西医治疗,治疗组在对照组基础上结合脑心通胶囊治疗。两组疗程均为4周。比较两组治疗疗效,治疗前后NIHSS评分、细胞炎症因子、凝血功能和血液流变学水平的影响,及不良反应发生情况。结果:治疗组总有效率(91.84%)高于对照组(73.47%),且有统计学意义(P0.05);治疗组治疗后NIHSS评分低于对照组(t值=11.681,P0.05);治疗组治疗后MCP-1和hs-CRP水平低于对照组(t值=18.060、10.528,P0.05);治疗组治疗后PT、APTT水平水平高于对照组而D-二聚体水平低于对照组(t值=17.054、10.787、10.579,P0.05);治疗组治疗后血浆黏度、全血黏度高切、全血黏度低切水平低于对照组(t值=6.869、5.754、7.609,P0.05);两组肝肾功能、心电图、血常规均未见异常,且无明显药物不良反应。结论:脑心通胶囊治疗急性脑梗死患者疗效明显,可降低血清MCP-1和hs-CRP水平,改善患者凝血功能和血液流变学异常,具有重要研究意义。
[Abstract]:Objective: to investigate the therapeutic effect of Naoxintong capsule on acute cerebral infarction patients and to investigate the effect of Naoxintong capsule on inflammatory cytokines. Methods: 98 patients with acute cerebral infarction were randomly divided into treatment group (n = 49) and control group (n = 49). The treatment group was treated with Naoxintong capsule on the basis of the control group. The course of treatment in both groups was 4 weeks. The therapeutic efficacy, NIHSS score and cytokines were compared before and after treatment. Results: the total effective rate of the treatment group (91.84) was higher than that of the control group (73.47). And there was statistical significance (P0.05). The NIHSS score of the treatment group was lower than that of the control group (P < 11.681). After treatment, the levels of MCP-1 and hs-CRP in the treatment group were lower than those in the control group. After treatment, the level of PTT APTT in the treatment group was higher than that in the control group, while the level of D-dimer was lower than that in the control group. The plasma viscosity and whole blood viscosity of the treatment group were high and the low shear level of the whole blood viscosity was lower than that of the control group. Liver and kidney function, electrocardiogram, blood routine were not abnormal, and there was no obvious adverse drug reaction. Conclusion: Naoxintong capsule is effective in treating acute cerebral infarction patients. It is of great significance to reduce serum MCP-1 and hs-CRP levels and improve coagulation function and hemorheology abnormality.
【作者单位】：绍兴文理学院附属医院内科;
【分类号】：R743.3
【正文快照】： 脑梗死是常见的一种脑血管疾病,认为其发生与血管内皮损伤、血栓形成、自由基损伤、血小板聚集及血黏度升高等密切相关[1-2]。近年来急性脑梗死发病率呈不断上升趋势,严重影响人们身心健康和生活质量[3]。目前,单纯采用西医治疗急性脑梗死患者效果并不十分理想。脑心通胶囊是

【相似文献】