血清非高密度脂蛋白胆固醇对缺血性脑卒中患者急性期神经功能损害的影响

发布时间：2018-01-24 07:46

本文关键词： 血脂异常非高密度脂蛋白胆固醇急性缺血性卒中神经功能损害　出处：《中国动脉硬化杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨血清非高密度脂蛋白胆固醇(non-HDLC)对缺血性脑卒中急性期神经功能损害的影响及其在风险评估中的临床价值。方法选择符合入组条件的急性缺血性卒中患者共611例,应用美国国立卫生研究院卒中量表(NIHSS)、中国脑卒中患者临床神经功能缺损程度评分量表(1995)(CSS)、欧洲版神经功能缺损评分(ESS)以及日常生活能力评定量表Barthel指数(BI)评价神经功能。同时测定空腹血糖、糖化血红蛋白(HbA1c)、血清高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDLC)等生化指标,并计算出non-HDLC的含量,比较non-HDLC高水平组与理想水平组患者NIHSS、CSS、ESS、BI分值,以探讨高non-HDLC水平与急性缺血性卒中神经功能损害的关系。结果与non-HDLC理想水平组患者相比,高non-HDLC水平组患者体质指数高、NIHSS、CSS评分高(P0.05),ESS和BI分值低(P0.05)。血清TC、TG、LDLC、Hcy、空腹血糖和HbA1c水平高,HDLC水平低(P0.05)。相关分析发现,随着non-HDLC水平升高,急性缺血性卒中神经功能损害的危险性明显增加。结论 Non-HDLC水平增高是缺血性脑卒中患者急性期神经功能损害的危险因素,可作为缺血性脑卒中神经功能损害危险评估的有效靶点。
[Abstract]:Objective to study the serum non-HDLC of non-high density lipoprotein cholesterol. Methods 611 patients with acute ischemic stroke were selected. The National Institutes of Health Stroke scale (NIHSS) was used to evaluate the clinical neurological impairment of stroke patients in China. Nerve function was evaluated by European version of neurologic impairment scale (ESS) and activity of Daily living (ADL) rating scale (Barthel). Fasting blood glucose was measured at the same time. Glycosylated hemoglobin (HbA1cU), serum Gao Min C-reactive protein (hs-CRPN), homocysteine (Hcyl), total cholesterol (TCX), triglyceride (TG). High density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDL-C) were used to calculate the content of non-HDLC. To compare the scores of non-HDLC in high level group and ideal group. To investigate the relationship between high non-HDLC level and neurological impairment in patients with acute ischemic stroke. Patients with high non-HDLC level had high BMI and high non-HDLC scores (P 0.05) and low BI scores (P 0.05). Hcy, fasting blood glucose and HbA1c level were high and low (P 0.05). Correlation analysis showed that with the increase of non-HDLC level. Conclusion the increased level of Non-HDLC is a risk factor for acute neurological impairment in patients with acute ischemic stroke. It can be used as an effective target for risk assessment of neurological impairment in ischemic stroke.
【作者单位】：天津医科大学研究生院;天津市环湖医院中医科;天津市环湖医院神经内科三病区;
【基金】：天津市科技计划项目(13ZCZDSY0 1600) 天津市卫生局科技重点项目(13K G121)
【分类号】：R743.3
【正文快照】： 3.天津市环湖医院神经内科三病区,天津市300350)中国缺血性卒中发病率远远高于西方国家,并且呈现高死亡率、高复发率、高致残率特点。其急性期易造成诸多神经功能损害,如意识不清、凝视、视野缺损、面瘫、肢体运动损伤、共济功能受损、感觉减退、语言功能减退等。血脂异常是缺

【相似文献】