定痫丸联合丙戊酸钠治疗癫痫大发作的临床研究

发布时间：2018-01-25 16:16

本文关键词： 癫痫大发作定痫丸丙戊酸钠临床研究　出处：《南京中医药大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：观察研究定痫丸联合丙戊酸钠片治疗癫痫大发作的临床效果,从而为癫痫患者选择中西医综合治疗提供可靠的临床依据。方法：使用随机平行对照方法,选取2012年9月至2013年8月期间在苏州市吴江区中医医院治疗的癫痫患者一共64名,分为对照组(30名)：单用口服丙戊酸钠片治疗癫痫(0.2g/次,3次/d),口服；实验组(34名)：在对照组的基础上加用定痫丸(4g/次,早晚口服),连续治疗12个月,每半年为一个疗程,每个疗程结束后统计两组患者在治疗期间癫痫的发作次数、癫痫发作的持续时间、癫痫发作的严重程度积分,整个实验结束后统计不良反应的发生,所有患者均由同一位医师进行统计和评价,实验数据采用SPSS19.0软件进行统计学分析。结果：(1)在癫痫的发作频率、持续时间和症状积分上面,治疗组在第一疗程和第二疗程上均优于对照组(P0.05),差异有统计学意义；(2)在不良反应的发生上两组数据差异无统计学意义(P0.05)。结论：定痫丸联合丙戊酸钠治疗癫痫大发作的效果明显优于单用丙戊酸钠,且并不增加不良反应的发生,值得临床推广运用。
[Abstract]:Objective: to observe and study the clinical effect of Dingxian pills combined with sodium valproate in the treatment of epilepsy, so as to provide reliable clinical basis for the patients with epilepsy to choose comprehensive treatment of traditional Chinese and western medicine. Methods: a randomized parallel control method was used. A total of 64 epileptic patients were selected from September 2012 to August 2013 who were treated in traditional Chinese Medicine Hospital of Wu Jiang District of Suzhou City. The patients were divided into control group (n = 30): oral sodium valproate tablet was used only to treat epilepsy with 0.2 g / 3 / d. Experimental group (n = 34): on the basis of the control group, Dingxian pills were given 4g / time, orally orally in the morning and evening, for 12 months continuously, every six months as a course of treatment. At the end of each course, the number of seizures, the duration of seizures, the severity of epileptic seizures, and the occurrence of adverse reactions after the treatment of the two groups were counted. All the patients were statistically evaluated by the same physician. The experimental data were statistically analyzed by SPSS19.0 software. Results: 1) the seizure frequency, duration and symptom score of epilepsy. The treatment group was better than the control group in the first course and the second course of treatment, the difference was statistically significant. There was no significant difference between the two groups in the occurrence of adverse reactions (P 0.05). Conclusion: the effect of Dingxian pills combined with valproate sodium in the treatment of epileptic seizures is significantly better than that of sodium valproate alone. And does not increase the occurrence of adverse reactions, worthy of clinical application.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.1

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