丁苯酞对脑白质疏松患者大脑中动脉血流速度和外周血内皮微粒的作用

发布时间：2018-01-27 07:19

本文关键词： 丁苯酞脑白质疏松大脑中动脉血流速度内皮微粒　出处：《中风与神经疾病杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨丁苯酞对脑白质疏松(LA)患者大脑中动脉血流速度和外周血内皮微粒(CD31~+/CD42b~-、CD144~+、CD62E~+)的作用。方法收集我院LA患者,其中轻度LA1组58例,中度LA2组30例,重度LA3组15例;收集同期健康体检为非脑白质疏松者NLA组50例;按随机数字表法将各组随机分为对照组和丁苯酞组。对照组给予常规治疗,丁苯酞组在常规治疗+丁苯酞软胶囊0.2 g口服,每日3次,治疗疗程为12 w。各组均于治疗前后测定大脑中动脉平均流速(Vm)、收缩期峰值流速(Vs)、和博动指数(PI);流式细胞仪检测外周血内皮细胞微粒CD31+/CD42b-、CD144+、CD62E+的表达百分率。结果 LA2、LA3组的各组12 w后较入组时Vs、Vm增快,PI值降低(P0.05),丁苯酞组较对照组变化更明显(P0.05);LA各组12 w后较入组时CD31~+/CD42b~-、CD144~+表达下降,CD62E~+表达升高(P0.05),丁苯酞组较对照组变化更明显(P0.05)。结论丁苯酞软胶囊可改善脑白质疏松患者脑血流情况,外周血内皮细胞微粒可早期反应脑血管的内皮调节功能,有望成为一种评估脑微血管血流情况的重要指标。
[Abstract]:Objective to investigate the effect of butyphthalide on the blood flow velocity of middle cerebral artery and peripheral blood endothelial microparticle CD31 ~ / / CD42b ~ + -CD144 ~ ~ in patients with leukoaraiosis (LAA). Methods 58 patients with mild LA1, 30 patients with moderate LA2 and 15 patients with severe LA3 were collected. 50 cases of NLA group with non-leukoaraiosis in the same period were collected. Each group was randomly divided into control group and butyphthalide group according to random digital table. The control group was treated with routine therapy. Butyphthalide group was treated with butyphthalide soft capsule 0.2 g orally three times a day. The course of treatment was 12 ws.The mean velocity of middle cerebral artery (MCAV), peak systolic velocity (VsN) and peak systolic velocity (Pi) were measured before and after treatment. Flow cytometry was used to detect the percentage of CD31 / CD42b-CD144 CD144 CD62E expression in peripheral blood endothelial cells. Results LA2. After 12 weeks, the Pi value of VsTV-M in LA3 group was significantly lower than that in the control group, and that in butyphthalide group was more obvious than that in the control group. After 12 weeks, the expression of CD31- / / CD42bP144~ decreased and the expression of CD62E~ increased (P0.05). Conclusion Butylphthalide soft capsule can improve the cerebral blood flow in patients with leukoaraiosis, and the peripheral blood endothelial cell particles can respond to the endothelial regulation function of cerebral vessels in the early stage. It is expected to be an important index to evaluate cerebral microvascular blood flow.
【作者单位】：西南医科大学附属医院神经内科;
【基金】：基金项目:四川省卫生厅(110368)
【分类号】：R743
【正文快照】： 脑白质疏松症(Leukoaraiosis,LA)是一个影像学概念,头部MRI表现为T1低信号、T2高信号,主要是一种弥漫性脑缺血所致的神经传导纤维脱髓鞘疾病。血管内皮微粒是内皮细胞在激活或者凋亡时释放出直径约为0.1~1.0μm的小囊泡[1,2],是血管内皮损伤的特异性分子标志,在正常人机体循环

【相似文献】