老年部分性癫痫患者睡眠结构与听觉事件相关电位的关系

发布时间：2018-02-01 16:56

本文关键词： 部分性癫痫睡眠结构听觉事件相关电位　出处：《中国老年学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的探讨老年部分性癫痫患者睡眠结构与听觉事件相关电位的关系。方法老年部分性癫痫患者138例为观察组,同期选取健康体检者130例为对照组。比较两组睡眠参数、Epworth嗜睡量表(ESS)评分和听觉事件相关电位参数(N1、N2、P2、P3潜伏期、波幅)。结果观察组总睡眠时间、睡眠效率、非快速眼动睡眠3期和4期、快速眼动睡眠期占总睡眠时间的百分比低于对照组,非快速眼动睡眠1期、2期、清醒期占总睡眠时间百分比和ESS评分高于对照组(P0.05)。总记录时间、睡眠潜伏期、快速眼动睡眠潜伏期、觉醒次数与对照组比较差异无统计学意义(P0.05)。Fz、Cz、Pz记录点N1潜伏期和Pz记录点P2潜伏期与对照组比较差异无统计学意义(P0.05),其余听觉事件相关电位参数潜伏期均较对照组延长(P0.05)。Fz、Cz、Pz记录点N1、N2、P2、P3波幅与对照组比较差异无统计学意义(P0.05)。听觉事件相关电位P3潜伏期与睡眠效率比较呈负相关(r=-0.420,P0.05),与非快速眼动睡眠3期和4期占总睡眠时间百分比呈负相关(r=-0.463,P0.05),与ESS评分呈正相关(r=0.532,P0.05)。结论老年部分性癫痫患者存在睡眠结构异常,认知功能损害。而脑电图夜间睡眠监测和听觉事件相关电位监测,有助于早期发现患者睡眠结构异常和认知功能受损情况,从而及时采取措施阻断认知功能损害、改善患者生活质量。
[Abstract]:Objective to investigate the relationship between sleep structure and auditory event-related potentials in elderly patients with partial epilepsy. In the same period, 130 healthy persons were selected as the control group. The sleep parameters, Epworth sleepiness scale (ESS) and auditory event-related potentials (AEP) were compared between the two groups. Results the total sleep time, sleep efficiency, non-rapid eye movement sleep stage 3 and 4, the percentage of rapid eye movement sleep stage to total sleep time in the observation group were lower than those in the control group. The percentage of total sleep time and ESS score of non-REM sleep stage 1 and 2 were higher than that of control group (P 0.05). The total recording time, sleep latency and REM sleep latency were higher than those in the control group (P < 0.05). There was no significant difference in the number of awakenings between the control group and the control group (P 0.05). There was no significant difference in N1 latency and P2 latency between Pz recording point and control group (P0.05). The latency of the other auditory event-related potential parameters was significantly longer than that of the control group (P 0.05) .FZ CzPz recording point N _ (1) N _ (2) N _ (2) P _ (2). There was no significant difference between P3 amplitude and control group (P 0.05). There was a negative correlation between P3 latency and sleep efficiency. There was a negative correlation with the percentage of non-REM sleep stage 3 and 4 in total sleep time, and a positive correlation with ESS score. Conclusion there are abnormal sleep structure and cognitive impairment in elderly patients with partial epilepsy, while EEG sleep monitoring and auditory event-related potential monitoring. It is helpful for early detection of abnormal sleep structure and impairment of cognitive function, so as to take timely measures to block the impairment of cognitive function and improve the quality of life of patients.
【作者单位】：遵义市第一人民医院神经内科二病区;
【基金】：基金项目:老年性痴呆防治研究科技创新团队[No.遵市科合社字(2014)27号]
【分类号】：R742.1
【正文快照】： 癫痫作为一种大脑神经元过度、反复超同步发放所引起的发作性脑功能障碍,具有发作突然、形式多样等特点[1]。合并睡眠障碍后,75%患者出现日间乏力、头晕等症状,可能与痫样放电所致的夜间睡眠结构改变和睡眠质量差等因素有关[2];而睡眠结构的异常改变又能导致痫样放电的增加,形

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