同型半胱氨酸测定在急性脑梗塞合并颈动脉病变的临床应用价值分析

发布时间：2018-02-07 15:41

本文关键词： 急性脑梗塞血浆同型半胱氨酸颈动脉病变　出处：《中国临床解剖学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨急性脑梗塞伴颈动脉病变同血同型半胱氨酸水平的相关性。方法将215例初发急性脑梗塞患者根据其空腹同型半胱氨酸(Hcy)值分为低同型半胱氨酸组103例及高同型半胱氨酸组112例。主要比较两组脑梗塞患者斑块和颈动脉狭窄的发生率以及严重程度。结果斑块以及严重的动脉狭窄更容易发生在急性脑梗塞高Hcy组。血浆Hcy的水平与斑块以及软斑的数量具有正相关性(kendall相关系数为0.145,P=0.0060.05);血浆Hcy的水平与重度动脉狭窄的发生率呈正相关(kendall相关系数为0.359,P=0.0000.05)。结论急性脑梗塞患者血浆Hcy水平与颈动脉斑块和狭窄发生率呈正相关,提示积极干预高同型半胱氨酸血症有助于预防颈动脉病变。
[Abstract]:Objective to investigate the correlation between acute cerebral infarction with carotid artery disease and serum homocysteine level. Methods 215 patients with acute cerebral infarction were divided into low homocysteine group (n = 103) and low homocysteine group (n = 103). The incidence and severity of plaque and carotid artery stenosis in patients with cerebral infarction were compared. Results plaque and severe arterial stenosis were more likely to occur in patients with acute cerebral infarction with high Hcy. There was a positive correlation between plasma Hcy level and the number of plaques and soft spots. The correlation coefficient between plasma Hcy level and the incidence of severe arterial stenosis was 0.145 and 0.145, respectively. Conclusion the plasma Hcy level in patients with acute cerebral infarction is 0.359mg / kg and 0.0000.050.Conclusion Plasma Hcy levels in patients with acute cerebral infarction are positively correlated with the incidence of severe arterial stenosis. There was a positive correlation with the incidence of carotid plaque and stenosis. It suggests that active intervention of hyperhomocysteinemia is helpful to prevent carotid artery disease.
【作者单位】：南京市溧水区人民医院神经内科;
【分类号】：R743.33

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