丁苯酞软胶囊对中青年缺血性卒中患者认知功能的影响

发布时间：2018-02-11 14:26

本文关键词： 认知障碍丁苯酞简易精神状态评价量表血管内皮生长因子侧枝循环　出处：《中国新药杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的:观察丁苯酞软胶囊治疗青中年缺血性卒中患者认知功能障碍的疗效,并初步探讨其作用机制。方法:80例青中年急性缺血性卒中合并认知功能障碍患者随机分为对照组和治疗组,每组各40例。对照组给予常规治疗,治疗组加服丁苯酞软胶囊,每次0.2 g,tid,20 d为1个疗程,间隔10 d,共3个疗程。治疗后1个月和3个月,比较2组患者简易精神状态评价(MMSE)量表评分、血清血管内皮生长因子(vascular endothelial growth factor,VEGF)及血管侧枝循环开放率。结果:治疗后1月和3月,2组患者MMSE评分明显提高,同组治疗前后比较差异有统计学意义(P0.05),且治疗组MMSE评分增高程度明显高于同期对照组,治疗后1月组间比较差异无统计学意义(P0.05),治疗后3月组间比较差异有统计学意义(P0.05)。治疗后1月和3月,2组患者血清VEGF水平呈先升后降趋势,同组治疗前后比较差异有统计学意义(P0.05),且治疗组上升幅度更明显,组间比较差异有统计学意义(P0.05)。治疗后3月,对照组与治疗组侧枝循环开放率分别为57.5%和80%,组间比较差异有统计学意义(P0.05)。结论:丁苯酞可有效改善青中年急性缺血性卒中患者的认知功能障碍,其作用机理可能与诱发内源性VEGF表达、促进新生血管形成有关。
[Abstract]:Objective: to observe the efficacy of butyphthalide soft capsule in the treatment of cognitive dysfunction in young and middle-aged patients with ischemic stroke. Methods 80 young and middle-aged patients with acute ischemic stroke complicated with cognitive dysfunction were randomly divided into control group and treatment group with 40 cases in each group. The control group was given routine treatment and the treatment group was treated with butyphthalide soft capsule. A course of treatment of 0.2 g tid for 20 days was used, with an interval of 10 days for 3 courses of treatment. After 1 month and 3 months of treatment, the scores of MMSE scale were compared between the two groups. Serum vascular endothelial growth factor (VEGF) and the open rate of collateral circulation. Results: the MMSE scores of the two groups were significantly increased after treatment on January and March. The difference before and after treatment in the same group was statistically significant (P 0.05), and the MMSE score in the treatment group was significantly higher than that in the control group. There was no significant difference between the two groups after treatment on January (P 0.05), but there was a significant difference between the two groups after treatment on March (P 0.05). The serum VEGF levels in the two groups increased first and then decreased after treatment in January and January. The difference before and after treatment in the same group was statistically significant (P 0.05), and the increase was more obvious in the treatment group. The difference between the two groups was statistically significant (P 0.05). March after treatment, there was no significant difference between the two groups. The open rate of collateral circulation in the control group and the treatment group were 57.5% and 80 respectively, and the difference between the two groups was statistically significant (P 0.05). Conclusion: butyphthalide can effectively improve cognitive dysfunction in young and middle-aged patients with acute ischemic stroke. The mechanism may be related to the induction of endogenous VEGF expression and the promotion of neovascularization.
【作者单位】：襄阳市中心医院(湖北文理学院附属医院)康复医学科;襄阳市中心医院(湖北文理学院附属医院)神经内科;
【分类号】：R743.3

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