阻塞性睡眠呼吸暂停低通气综合征与后循环短暂性脑缺血发作的相关性临床研究

发布时间：2018-02-14 12:00

本文关键词： 阻塞性睡眠呼吸暂停低通气综合征后循环缺血短暂性脑缺血发作动脉粥样硬化同型半胱氨酸　出处：《国际神经病学神经外科学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与后循环短暂性脑缺血发作(TIA)的相关性及其发病机制。方法选取我院住院治疗的30例后循环TIA患者作为病例组;34例非后循环TIA患者作为对照组。收集所有研究对象的基本临床资料及多导睡眠检测结果。回顾性分析不同程度OSAHS在两组中的分布特点。采用二元Logistic回归分析法分析后循环TIA与其危险因素及OSAHS之间的相关性;采用Spearman分析法分析OSAHS与后循环TIA危险因素之间的关系。结果病例组OSAHS患者例数为24例,对照组为18例,差异具有统计学意义(P0.05);病例组重度OSAHS例数11例,对照组2例,差异具有统计学意义(P0.05);重度OSAHS与后循环TIA之间有相关性。糖尿病、低密度脂蛋白(LDL)、甘油三酯、BMI、同型半胱氨酸(Hcy)和吸烟为后循环TIA的独立危险因素;而OSAHS不是后循环TIA的独立危险因素。OSAHS与吸烟、高血压、BMI和Hcy等危险因素有显著相关性。结论 OSAHS是后循环TIA发病的危险因素之一,但不是独立危险因素。OSAHS通过与吸烟、高血压、BMI和同型半胱氨酸等危险因素相互作用,促进后循环TIA的发病。
[Abstract]:Objective to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and posterior circulation transient ischemic attack (TIA) and its pathogenesis. The patients with non-posterior circulation TIA were used as control group. The basic clinical data and polysomnography were collected from all the subjects. The distribution of OSAHS in two groups was analyzed retrospectively. Binary Logistic regression analysis was used to analyze the distribution of OSAHS in the two groups. The correlation between posterior circulation TIA and its risk factors and OSAHS; Spearman analysis was used to analyze the relationship between OSAHS and risk factors of posterior circulation TIA. Results there were 24 cases of OSAHS in the case group and 18 cases in the control group (P 0.05), 11 cases of severe OSAHS in the case group and 2 cases in the control group. Significant difference was found between severe OSAHS and posterior circulation TIA. Diabetes, low density lipoprotein (LDL), triglyceride (OSAHS), homocysteine (Hcyl) and smoking were independent risk factors for hind cycle TIA. OSAHS is not an independent risk factor for posterior circulation TIA. There is a significant correlation between OSAHS and smoking, hypertension and Hcy. Conclusion OSAHS is one of the risk factors of posterior circulation TIA, but it is not an independent risk factor. High blood pressure and homocysteine and other risk factors interact to promote the incidence of posterior circulation TIA.
【作者单位】：新疆医科大学第二附属医院神经内科;新疆医科大学第一附属医院神经内科;
【分类号】：R743.31;R766

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