青少年肌阵挛癫痫患者认知功能的研究

发布时间：2018-02-16 23:27

本文关键词： 青少年肌阵挛癫痫蒙特利尔认知评估量表中国成人韦氏智力量表症状自评量表认知功能　出处：《中国康复理论与实践》2017年06期 　论文类型：期刊论文

【摘要】：目的对青少年肌阵挛癫痫(JME)患者的认知功能及心理精神状态进行评测,并探讨相关危险因素。方法 2011年9月至2014年2月21例JME患者作为患者组,同时选择18例年龄、性别及教育程度等与之相匹配的健康受试者作为对照组。采用蒙特利尔认知评估量表(MoCA)和中国成人韦氏智力量表(WAIS-RC)对认知功能进行评测;采用症状自评量表(SCL-90)对心理精神状态进行测试;采用Logistic回归分析其危险因素。结果两组MoCA评分无显著性差异(t=-1.544,P=0.131)。患者组的语言智商、操作智商及全量表智商均显著低于对照组(t4.119,P0.001)。患者组SCL-90评分在人际关系敏感、抑郁、焦虑、敌对、恐怖、偏执及精神病性7项高于对照组(t2.480,P0.05)。Logistic回归分析提示,服用丙戊酸的患者语言智商下降(B=-3.064,OR=0.047,95%CI=0.002~0.920,P=0.044)。结论 JME患者的语言智商、操作智商及全量表智商下降,在人际关系敏感、抑郁、焦虑、敌对、恐怖、偏执及精神病性症状方面存在不同程度的障碍。服用丙戊酸是JME患者认知功能下降的危险因素。
[Abstract]:Objective to evaluate the cognitive function and mental state of juvenile patients with myoclonic epilepsy, and to explore the risk factors. Methods from September 2011 to February 21st 2014, 18 patients with JME were selected as the group of patients, and 18 patients of age were selected at the same time. The healthy subjects matched with gender and educational level were used as control group. The cognitive function was evaluated by the Montreal Cognitive Assessment scale (MoCA) and the Chinese Adult Wechsler Intelligence scale (WAIS-RC). The mental state was tested by symptom Checklist-90 (SCL-90), and the risk factors were analyzed by Logistic regression analysis. Results there was no significant difference in MoCA score between the two groups. The scores of SCL-90 in the patient group were significantly lower than those in the control group in terms of interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoid ideation and psychosis. Logistic regression analysis showed that the scores were significantly higher than those in the control group. The language intelligence quotient of patients taking valproic acid was 0.047 / 95. Conclusion the language intelligence quotient, operation intelligence quotient and whole scale intelligence quotient of JME patients are decreased, and they are sensitive to interpersonal relationship, depression, anxiety, hostility, terror, etc. Paranoia and psychotic symptoms have different degrees of disorder. Valproic acid is a risk factor for cognitive impairment in patients with JME.
【作者单位】：首都医科大学宣武医院神经内科;首都医科大学附属北京潞河医院神经内科;北京顺义区医院神经内科;
【基金】：国家自然科学基金项目(No.81571267;No.30800366) 首都发展基金自主创新专项(No.2016-2-2013)
【分类号】：R742.1

【相似文献】