急性脑梗死患者中饮酒量对尿酸的影响及尿酸与血脂的相关性

发布时间：2018-02-24 14:25

本文关键词： 饮酒量急性脑梗死尿酸血脂胰岛素抵抗　出处：《延边大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的检测男性急性脑梗死(缺血性脑卒中)患者血清尿酸、血脂水平,探讨不同饮酒量对血清尿酸水平的影响及尿酸与血脂的相关性。方法选取延边大学附属医院2015年2月-2016年1月诊断为急性脑梗死的279例住院男性患者作为研究对象,平均年龄为58.31±8.52岁。根据饮酒量不同分为不饮酒组、少量饮酒组、中量饮酒组、过量饮酒组。所有患者中尿酸420μmol/L者组成高尿酸血症组(35例),其余患者组成尿酸正常组(244例)。测定血清尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等,并计算TG/HDL-C,评价饮酒量与血尿酸之间的关系以及血尿酸与TG、TC、HDL-C、LDL-C、TG/HDL-C的相关性。结果1.不饮酒组、少量饮酒组、中量饮酒组、过量饮酒组之间,年龄、体重指数、高血压病史、糖尿病病史、NIHSS评分差异无统计学意义(P0.05)。不同饮酒量组间吸烟史差异有统计学意义(P0.05)；少量饮酒组、大量饮酒组的吸烟史显著高于不饮酒组(P0.05)；少量饮酒组、中量饮酒组、大量饮酒组的吸烟史无显著性差异(P0.05)。2.不同饮酒量组间UA水平差异有统计学意义(P0.05)。大量饮酒组的尿酸水平高于少量及中量饮酒组的尿酸水平,差异有统计学意义(P0.05)；大量饮酒组的尿酸水平高于不饮酒组的尿酸水平,但差异无统计学意义(P0.05)。3.高尿酸血症组与尿酸正常组的年龄、BMI、高血压病史、糖尿病病史、吸烟史、饮酒量、NIHSS评分之间的差异均无统计学意义(P0.05)4.高尿酸血症组的TC、TG、LDL-C、TG/HDL-C高于尿酸正常组,差异有统计学意义(P0.05)。高尿酸血症组的HDL-C水平低于尿酸正常组的HDL-C水平,但差异无统计学意义(P0.05)。5. UA与TC、TG、LDL-C、HDL-C、TG/HDL-C的相关系数分别为0.219、0.264、0.132、-0.075、0.238、其中与TC, TG, LDL-C, TG/HDL-C呈显著正相关(P0.05)。结论1.在男性急性脑梗死患者中,饮酒量与血清尿酸水平密切相关,与少到中量饮酒相比,大量饮酒可导致尿酸水平升高。2.在男性急性脑梗死患者中,尿酸与血脂代谢、胰岛素抵抗密切相关。3.在男性急性脑梗死患者中,尿酸与TC、TG、LDL-C、TG/HDL-C呈正相关。
[Abstract]:Objective to detect the levels of serum uric acid and blood lipid in male patients with acute cerebral infarction. To explore the effect of alcohol intake on serum uric acid level and the correlation between uric acid and blood lipids. Methods 279 hospitalized male patients diagnosed as acute cerebral infarction from February 2015 to January 2016 in Yanbian University Hospital were selected as the study objects. The average age was 58.31 卤8.52 years old. All patients were divided into hyperuricemia group (n = 35) and control group (n = 244). Serum uric acid, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density (HDLC) were measured. Lipoprotein cholesterol, HDL-C, etc. To evaluate the relationship between alcohol consumption and serum uric acid, and the correlation between serum uric acid and TGG / HDL-C, the results were as follows: 1. Age, body mass index, hypertension history, age, age, body mass index, and history of hypertension were calculated in non-alcohol drinking group, moderate alcohol drinking group, moderate alcohol drinking group, moderate drinking group, moderate drinking group, and moderate alcohol drinking group, as well as the correlation between serum uric acid and TGG / HDL-C. There was no significant difference in NIHSS score of diabetes mellitus history (P 0.05). There was a significant difference in smoking history among different alcohol consumption groups (P 0.05); the smoking history of heavy drinking group was significantly higher than that of non-alcohol drinking group (P 0.05); the smoking history of low alcohol drinking group was significantly higher than that of non-alcohol drinking group, while that of moderate alcohol drinking group was lower than that of moderate alcohol drinking group. There was no significant difference in smoking history in heavy drinking group (P 0.05). There was significant difference in UA level among different drinking groups (P 0.05). The uric acid level in heavy drinking group was higher than that in small and moderate drinking group. The level of uric acid in the heavy drinking group was higher than that in the non-drinking group, but there was no significant difference in the level of uric acid between the hyperuricemia group and the normal uric acid group. The age of BMIs, the history of hypertension, the history of diabetes, and the history of smoking in hyperuricemia group were significantly higher than those in non-drinking group, but there was no significant difference in the level of uric acid between hyperuricemia group and normal uric acid group. There was no significant difference in NIHSS score between the two groups. The levels of HDL-C in hyperuricemia group were significantly higher than those in normal uric acid group, and the HDL-C level in hyperuricemia group was lower than that in normal uric acid group. But there was no significant difference (P 0.05). The correlation coefficient between UA and serum uric acid level was 0.21919 ~ 0.264 ~ 0.262 ~ (-0.075) ~ 0.238, respectively, and there was a significant positive correlation between serum uric acid level and alcohol consumption in male patients with acute cerebral infarction. Conclusion (1) in male patients with acute cerebral infarction, alcohol consumption is closely related to serum uric acid level, compared with moderate to moderate alcohol consumption, and there is a significant positive correlation between serum uric acid level and serum uric acid level in male patients with acute cerebral infarction, and there is a significant positive correlation between UA and LDL-C and TG/HDL-C in male patients with acute cerebral infarction, compared with moderate to moderate alcohol consumption, there is a significant correlation between alcohol consumption and serum uric acid level in male patients with acute cerebral infarction. 2. In male patients with acute cerebral infarction, uric acid was closely related to blood lipid metabolism and insulin resistance. In male patients with acute cerebral infarction, uric acid was positively correlated with TGLDL-C TG- / HDL-C.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R743.3

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