羟乙基淀粉对急性缺血性脑卒中患者肾功能的影响

发布时间：2018-02-25 03:30

本文关键词： 羟乙基淀粉急性缺血性脑卒中肾功能　出处：《郑州大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的:探究羟乙基淀粉(HES)对急性缺血性脑卒中患者肾功能的影响。方法:选择急性缺血性脑卒中患者62例作为试验组,在常规治疗的基础上,给予HES130/0.4氯化钠500 mL静脉滴注,1次/d,疗程14 d。55例急性缺血性脑卒中患者作为对照组,给予常规治疗。收集入院时、治疗第7天、治疗第14天、治疗后第1个月及治疗后第3个月时的神经功能缺损程度(NIHSS评分)、日常生活能力指数(BI)及肾功能变化情况。结果:2组患者入院时的传统危险因素差异无统计学意义(P0.05)。治疗后试验组患者的NIHSS评分、BI均较对照组明显改善(P0.05);治疗期间肌酐、尿素氮、估计肾小球滤过率(e GFR)均有恶化趋势,但均逐渐恢复。结论:HES治疗急性缺血性脑卒中患者后,其生活质量可改善明显,肾功能在治疗后均逐渐恢复。
[Abstract]:Objective: to investigate the effect of hydroxyethyl starch (HES) on renal function in patients with acute ischemic stroke. Methods: 62 patients with acute ischemic stroke were selected as the experimental group, on the basis of routine treatment. HES130/0.4 500 mL sodium chloride was given intravenously once a day. The course of treatment was 14 d.55 patients with acute ischemic stroke as control group. NIHSS score, activity of daily living index (BI) and renal function were measured at the first month after treatment and at the third month after treatment. Results there was no significant difference in the traditional risk factors between the two groups at admission. After treatment, the NIHSS scores of the patients in the trial group were significantly improved than those in the control group. Urea nitrogen, estimated glomerular filtration rate (GFR), showed a tendency of deterioration, but gradually recovered. Conclusion the quality of life of patients with acute ischemic stroke can be improved obviously after treatment with 1: HES, and the renal function will gradually recover after treatment.
【作者单位】：郑州大学第五附属医院神经内科;
【分类号】：R743.3

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