大鼠蛛网膜下腔出血后兴奋性氨基酸对脑微循环的影响

发布时间：2018-02-26 21:49

本文关键词： 激光多普勒兴奋性氨基酸肾上腺髓质素海人酸　出处：《中国现代医学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨蛛网膜下腔出血后氧化应激链中兴奋性氨基酸对脑微循环的影响。方法颈内血管穿刺法制作大鼠蛛网膜下腔出血模型。实验共分3组,出血模型3天组与急性期组(对照)。其中,出血后3天组又分2组,一组大鼠确定海马CA3区,另一组确定侧脑室区,分别采用微量进样器直接注射兴奋性氨基酸类似物海人酸(KA)与肾上腺髓质素(ADM),激光多普勒监测,观察并对比三者脑表面局部血流灌注量的变化趋势。结果ADM能提高SAH后脑表面局部微循环血流灌注量,KA能、降低其脑表面局部微循环血流灌注量。结论SAH后产生的氧化应激链中兴奋性氨基酸能够显著降低脑表面局部微循环血流灌注量。
[Abstract]:Objective to investigate the effect of excitatory amino acids in oxidative stress chain on cerebral microcirculation after subarachnoid hemorrhage. The hemorrhage model group was divided into two groups: one group determined the CA3 area of hippocampus, the other group determined the lateral ventricular area, 3 days after bleeding, the rats were divided into two groups. The model group was divided into two groups: one group was divided into two groups, one group was the hippocampus CA3 area, the other group was the lateral ventricle area. The excitatory amino acid analogue kainic acid (kainic acid) and adrenal medullin (ADMN) were injected directly into the microsampler and monitored by laser Doppler. Results ADM could increase the amount of blood perfusion of local microcirculation on the surface of brain after SAH. Conclusion the excitatory amino acids produced in oxidative stress chain after SAH can significantly decrease the amount of regional microcirculation perfusion on brain surface.
【作者单位】：华北理工大学附属医院神经外科;河北省遵化市人民医院神经外科;华北理工大学基础医学院(河北省慢性疾病重点实验室唐山市慢性病临床基础研究重点实验室);
【基金】：河北省级重大医学项目(No:Zd2013093)
【分类号】：R743.35

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