硫辛酸联合依帕司他和硫辛酸治疗糖尿病周围神经病变临床疗效比较的Meta分析

发布时间：2018-03-01 00:23

本文关键词： 硫辛酸联合依帕司他硫辛酸糖尿病周围神经病变 Meta分析　出处：《中国医学科学院学报》2017年05期 　论文类型：期刊论文

【摘要】：目的比较硫辛酸联合依帕司他与硫辛酸治疗糖尿病周围神经病变(DPN)患者的临床疗效。方法收集2016年2月以前CNKI、CBM、维普、万方、Pub Med等数据库中硫辛酸联合依帕司他对比硫辛酸治疗DPN的临床试验资料,采用Cochrane系统及Jadad评分对文章进行质量评估,Rev Man5.3软件对多项研究结果的总体效应进行Meta分析。结果共纳入9项研究。Meta分析结果显示:硫辛酸显效率明显低于硫辛酸联合依帕司他[RR=0.58,95%CI(0.47,0.71),P0.00001],正中运动神经传导速度[WMD=-4.94,95%CI(-7.41,-2.46),P0.0001]、腓总运动神经传导速度[WMD=-5.08,95%CI(-7.68,-2.49),P=0.0001]、正中感觉神经传导速度[WMD=-4.24,95%CI(-6.20,-2.29),P0.0001]和腓总感觉神经传导速度[WMD=-3.66,95%CI(-5.02,-2.31),P0.00001]也明显低于联合用药。敏感性分析显示结果稳健。但纳入研究存在设计报道简单、主观指标少、随访时间短等问题。结论硫辛酸联合依帕司他可提高显效率,增加正中或腓总神经的运动神经传导速度和感觉神经传导速度。由于目前纳入文献质量普遍不高,需谨慎考虑此结论,希望有更多高质量的随机对照试验支持。
[Abstract]:Objective to compare the clinical efficacy of lipoic acid combined with epalcitrate and lipoic acid in the treatment of diabetic peripheral neuropathy (DPN). The clinical trial data of lipoic acid combined with epalcitrate in the database of Pub Med were compared with that of lipoic acid in the treatment of DPN. Cochrane system and Jadad score were used to evaluate the quality of the article. The overall effect of Man5.3 software on the results of many studies was analyzed by Meta. The results included 9 studies. Meta-analysis results showed that the apparent efficiency of lipoic acid was significantly lower than that of lipoic acid. The median motor nerve conduction velocity [WMD-4.94995 CI-7.41-2.46C], the total peroneal motor nerve conduction velocity (WMD-5.0895CI-7.68- 2.49P0.0001), the median sensory nerve conduction velocity (WMD-4.2495CI-6.20-2.29P0.0001) and the total peroneal nerve conduction velocity [WMD-5.0895CI-7.68-2.49C _ 0.0001], WMD-4.2495CI-6.20-2.29P0.0001 and WMD-3.695CI-5.695CI-5.02a -2.31P 0.00001 were also significantly lower than those of the combined drug. But included in the study there are simple reports of design, Conclusion the combination of lipoic acid and epalcitrate can increase the motor nerve conduction velocity and sensory nerve conduction velocity of the median or common peroneal nerve. This conclusion needs to be carefully considered and more high-quality randomized controlled trials are expected to support it.
【作者单位】：广州中医药大学附属深圳市宝安中医院(集团);广州中医药大学第一临床医学院;广州中医药大学中药学院;
【基金】：广州中医药大学大学生创新训练计划项目(201710572271)~~
【分类号】：R587.2;R747.9

【相似文献】