不同类型缺血性脑血管病血浆同型半胱氨酸水平与神经功能缺损程度的关系

发布时间：2018-03-01 05:29

本文关键词： 脑梗死短暂脑缺血发作同型半胱氨酸神经缺损　出处：《中国老年学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨不同类型缺血性脑血管病(ICVD)患者血浆同型半胱氨酸(Hcy)水平与神经缺损程度的关系。方法 ICVD患者82例,根据疾病类型分为脑梗死(CI)组59例和短暂性脑缺血发作(TIA)组23例,根据患者入院时美国国立神经缺损评分(NIHSS)分为重度神经缺损组(31~42分)18例、中度神经缺损组(16~30分)42例和轻度神经缺损组(0~15分)22例;选择同期体检中心的健康者30例作为对照组,测量各组血浆Hcy、纤维蛋白原(Fib)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果 CI组和TIA组Hcy、Fib、TG、TC、LDL-C均显著高于对照组(P0.05),HDL-C均显著低于对照组(P0.05);CI组Hcy、Fib、TG、TC、LDL-C均显著高于TIA组,HDL-C均显著低于TIA组(P0.05)。重度神经缺损组、中度神经缺损组和轻度神经缺损组Hcy、Fib、TG、TC、LDL-C均显著高于对照组(P0.05),重度神经缺损组Hcy、Fib、TG、TC、LDL-C显著高于中度神经缺损组和轻度神经缺损组(P0.05),中度神经缺损组Hcy、Fib、TG、TC、LDL-C显著高于轻度神经缺损组(P0.05),重度神经缺损组、中度神经缺损组HDL-C显著低于对照组和轻度神经缺损组(P0.05)。Prearson相关分析显示,不同类型和NIHSS评分与血浆Hcy和Fib呈正相关(P0.05)。结论 ICVD患者血浆Hcy和Fib及血脂异常升高,不同类型和NIHSS评分与血浆Hcy和Fib呈正相关。
[Abstract]:Objective to investigate the relationship between the plasma homocysteine homocysteine (Hcy) level and the degree of nerve defect in patients with different types of ischemic cerebrovascular diseases (ICVDs). Methods 82 patients with ICVD were included in this study. According to the type of disease, 59 patients were divided into CI group (59 cases) and 23 patients with transient ischemic attack (TIA) group, and 18 patients were divided into severe nerve defect group (18 cases) according to the American National nerve defect score (NIHSS) at admission. 42 cases of moderate nerve defect group and 22 cases of mild nerve defect group were selected as control group. The plasma levels of Hcyl, fibrinogen, triglyceride (TGG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) in each group were measured. Results the levels of HDL-C in CI group and TIA group were significantly higher than those in control group (P 0.05). The LDL-C levels of Hcystoma Fib#en0# TCN LDL-C in the irradiation group were significantly higher than those in the TIA group and the severe nerve defect group, which were significantly lower than those in the TIA group, which were significantly lower than those in the TIA group, and were significantly lower than those in the TIA group, which were significantly lower than those in the TIA group. The LDL-C levels of Hcyn FibTGG (TGG) TCN in moderate nerve defect group and mild nerve defect group were significantly higher than those in control group (P 0.05), while in severe nerve defect group, it was significantly higher than that in medium nerve defect group and mild nerve defect group (P 0.05), and in moderate nerve defect group, it was significantly higher than that in mild nerve defect group. In severe nerve defect group, it was significantly higher than that in mild nerve defect group (P < 0.05), and that in moderate nerve defect group was significantly higher than that in mild nerve defect group (P < 0.05). The lesion group was P0.05, and the severe nerve defect group, HDL-C in moderate nerve defect group was significantly lower than that in control group and mild nerve defect group. Prearson correlation analysis showed that different types and NIHSS scores were positively correlated with plasma Hcy and Fib. Conclusion Plasma Hcy and Fib and blood lipid in patients with ICVD are increased. Different types and NIHSS scores were positively correlated with plasma Hcy and Fib.
【作者单位】：铜陵市立医院神经内科;
【分类号】：R743.3

【相似文献】