高血压合并缺血性脑卒中患者血清同型半胱氨酸检测的临床价值及相关药物干预研究

发布时间：2018-03-03 01:23

本文选题：H型高血压　切入点：缺血性脑卒中　出处：《现代实用医学》2016年12期 　论文类型：期刊论文

【摘要】：目的分析高血压合并缺血性脑卒中患者血清同型半胱氨酸(Hcy)水平与疾病各因素的相关性,根据合并症情况与Hcy水平施加不同的药物干预,并评价干预效果。方法采用循环酶法检测194例高血压合并缺血性脑卒中患者的血清Hcy水平,分析血清Hcy水平与疾病各因素的相关性。按照疾病类型分成A组(H型高血压合并缺血性脑卒中组)98例,常规用药基础上口服马来酸依那普利叶酸片进行干预,B组(高血压合并缺血性脑卒中组)96例,常规用药的基础上口服依那普利进行干预并于干预2周、4周和3个月复查患者血清Hcy水平。结果影像学检查有无斑块与脑卒中既往史是高血压合并缺血性脑卒中患者血清Hcy水平的影响因素(均P0.05)。马来酸依那普利叶酸片对H型高血压合并缺血性脑卒中组进行干预后,2周、4周和3个月复测血清Hcy值呈逐步下降趋势(P0.05)。结论颈动脉斑块与脑卒中既往史是影响高血压合并缺血性脑卒中患者血清Hcy水平的因素,马来酸依那普利叶酸片对降低H型高血压合并缺血性脑卒中血清Hcy水平有一定的作用。
[Abstract]:Objective to analyze the correlation between serum homocysteine homocysteine (Hcy) level and various disease factors in patients with hypertension and ischemic stroke, and to apply different drug intervention according to the complication and Hcy level. Methods Serum Hcy levels in 194 patients with hypertension and ischemic stroke were measured by circulating enzyme method. To analyze the correlation between serum Hcy level and various factors of disease. According to the type of disease, 98 cases of hypertension complicated with ischemic stroke were divided into two groups: group A (n = 98), type H hypertension with ischemic stroke (n = 98). On the basis of routine medication, enalapril maleate folic acid tablets were taken orally for intervention in group B (96 cases of hypertension complicated with ischemic stroke). On the basis of routine medication, enalapril was administered orally and the serum Hcy levels were reexamined at 2 weeks, 4 weeks and 3 months after intervention. Results Imaging examination showed whether plaque and stroke had a history of hypertension complicated with ischemic stroke. The influencing factors of serum Hcy level in patients (all P 0.05). Enalapril maleate folic acid tablets intervention in patients with H type hypertension with ischemic stroke group after 2 weeks and 4 weeks and 3 months the serum Hcy levels showed a gradual downward trend of P0.050.Conclusion Cervical enalapril folic acid tablets in patients with hypertension with ischemic stroke group showed a gradual decline trend. Atherosclerotic plaque and past history of stroke were the factors influencing the serum Hcy level in hypertensive patients with ischemic stroke. Folic acid tablets of enalapril maleate can decrease the serum Hcy level in patients with H-type hypertension and ischemic stroke.
【作者单位】：武警浙江省总队医院(嘉兴);
【基金】：嘉兴市科技局项目(2014AY21055)
【分类号】：R544.1;R743.3

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