金匮通脉方联合阿替普酶溶栓治疗对溶栓时间窗外急性脑梗死区域组织灌注的影响

发布时间：2018-03-03 22:08

  本文选题：脑梗死/中西医结合疗法　切入点：溶栓时间窗外　出处：《中医研究》2016年12期 　论文类型：期刊论文

【摘要】：目的:观察金匮通脉方联合阿替普酶溶栓治疗对溶栓时间窗外急性脑梗死区域组织灌注的影响。方法:将50例溶栓时间窗外6~72 h急性脑梗死患者采用随机数字表法随机分为两组,两组均给予抗血小板、调脂、调控血压和血糖等常规治疗。对照组25例采用阿替普酶溶栓治疗;治疗组25例在对照组治疗基础上加服金匮通脉方(黄芪、全瓜蒌、薤白、益母草、丹参、山楂、制半夏),每日1剂,水煎服。两组均治疗14 d后判定疗效。结果:两组治疗后脑梗死中心区域CBV、CBF均较治疗前增加,MTT较治疗前缩短,但治疗组改善程度明显优于对照组(P0.01);治疗组治疗后脑梗死周围区域CBV、CBF均较治疗前增加(P0.01),且治疗组改善程度明显优于对照组(P0.01);治疗组治疗后脑梗死中心和周围区域的r CBV、r CBF均较治疗前明显增加(P0.01)。结论:金匮通脉方联合阿替普酶溶栓治疗溶栓时间窗外急性脑梗死能够改善患者脑梗死中心及其周围区域组织灌注,尤其对梗死周围组织灌注的改善较为明显,值得进一步研究和运用。
[Abstract]:Objective: to observe the effect of Jinkui Tongmai recipe combined with atropine enzyme thrombolytic therapy on tissue perfusion in acute cerebral infarction region outside thrombolytic time window. Methods: 50 patients with acute cerebral infarction outside the thrombolytic time window for 672 hours were treated with random digital table. Methods were randomly divided into two groups. Both groups were given routine treatment such as anti-platelet, regulating lipid, regulating blood pressure and blood sugar. 25 cases in the control group were treated with atropine enzyme thrombolytic therapy, and 25 cases in the treatment group were treated with Jinkui Tongmai recipe (Astragalus, Trichosanthes, macrostemon macrostemon) on the basis of the treatment of the control group. Herba Leonurus, Salvia miltiorrhiza, Hawthorn, Pinellia ternata, 1 dose per day, decoction of water were used to evaluate the curative effect of both groups after 14 days. Results: the CBV CBF in the central area of cerebral infarction after treatment in both groups was shorter than that before treatment, and the increase of MTT in the central area of cerebral infarction in both groups was shorter than that before treatment. However, the improvement of the treatment group was better than that of the control group (P 0.01), and the CBF of the treatment group was significantly higher than that of the control group (P 0.01), and the CBF of the treatment group was significantly better than that of the control group (P 0.01), and the center and surrounding area of the cerebral infarction after treatment in the treatment group were significantly better than those in the control group. Conclusion: Jinguitongmai decoction combined with atropine enzyme thrombolytic therapy for acute cerebral infarction outside the thrombolytic time window can improve the perfusion of cerebral infarction center and surrounding region in patients with acute cerebral infarction. Especially, the improvement of periinfarction tissue perfusion is obvious, which is worthy of further study and application.
【作者单位】： 驻马店市中医院;
【分类号】：R743.33
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本文编号：1562888