依达拉奉治疗急性脑出血的疗效分析

发布时间：2018-03-04 15:32

本文选题：脑出血　切入点：自由基清除剂　出处：《中国临床保健杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨依达拉奉对急性脑出血患者血清肿瘤坏死因子α(TNF-α)和白细胞介素-1(IL-1)水平的影响,并观察其治疗效果。方法将首次发病的急性脑出血患者90例,按病例对照研究方法随机分为对照组45例、治疗组45例,对照组是采用常规治疗,治疗组是在常规治疗基础上加用依达拉奉注射液30 mg+0.9%氯化钠注射液100 m L静脉滴注,2次/d,共14 d。比较两组患者于治疗前、后神经功能缺损程度(NIHSS)及日常生活活动量(ADL)评分,并进行疗效评定,检测患者血清TNF-α、IL-1水平的变化。结果治疗组在治疗后14 d NIHSS评分[(11.57±1.82)分]及ADL评分[(54.84±4.18)分]与对照组[(16.82±2.27)分、(45.13±3.93)分]相比,差异有统计学意义(均P0.05);治疗组临床疗效明显优于对照组(P0.05),其神经功能缺损程度明显改善,日常生活能力明显提高。治疗后,治疗组TNF-α[(13.06±2.90)ng/L]、IL-1[(4.31±2.23)ng/L]水平较对照组[(18.96±3.04)ng/L、(9.76±2.67)ng/L]比较,差异有统计学意义(均P0.05)。结论依达拉奉能减轻脑出血后炎性反应、清除自由基、改善神经功能缺损。
[Abstract]:Objective to investigate the effects of Edaravone on serum levels of tumor necrosis factor 伪 (TNF- 伪) and interleukin-1 (IL-1) in patients with acute intracerebral hemorrhage (AICH), and to observe the therapeutic effect of Edaravone. According to the method of case-control study, 45 cases were randomly divided into control group (n = 45), treatment group (n = 45) and control group (n = 45). The treatment group was treated with Edaravone injection 30 mg 0.9% NaCl injection 100ml intravenous drip twice a day for 14 days on the basis of routine treatment. The degree of neurological deficit and ADL scores were compared before and after treatment in the two groups. Results the NIHSS score [11.57 卤1.82] and the ADL score [54.84 卤4.18] in the treatment group were compared with those in the control group [16.82 卤2.27) and 45.13 卤3.93]. The difference was statistically significant (P 0.05), the clinical efficacy of the treatment group was significantly better than that of the control group (P 0.05), the degree of nerve function defect and the ability of daily living were obviously improved. After treatment, the levels of TNF- 伪 (13.06 卤2.90 ng / L) and IL-1 [4.31 卤2.23 ng / L] in the treatment group were significantly higher than those in the control group [18.96 卤3.04 ng / L, 9.76 卤2.67 ng / L]. Conclusion Edaravone can attenuate inflammatory reaction, eliminate free radicals and improve nerve function defect after cerebral hemorrhage.
【作者单位】：上海交通大学附属第九人民医院急诊科;
【基金】：上海高校青年教师培养资助基金(ZZjdyx13102)
【分类号】：R743.34

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