丁苯酞联合依达拉奉对急性脑梗死患者生活能力的改善

发布时间：2018-03-04 18:32

本文选题：丁苯酞　切入点：依达拉奉　出处：《血栓与止血学》2016年05期 　论文类型：期刊论文

【摘要】：目的研究丁苯酞注射液联合依达拉奉对急性脑梗死(ACI)患者生活能力的改善。方法选取120例ACI病人,随机分将患者分为对照组,丁苯酞治疗组,依达拉奉治疗组以及联合治疗组,每组各30例。对照组应用ACI常规治疗药物(阿司匹林,奥扎格雷),丁苯酞治疗组则在对照组基础上加用丁苯酞,依达拉奉治疗组在对照组基础上采用依达拉奉静脉滴注,联合治疗组则在对照组基础上联合应用丁苯酞与依达拉奉。采用脑卒中患者临床神经功能缺损程度评分标准(CSS)比较不同组别之间的患者神经功能恢复状况,用Barthel指数评定日常生活活动能力。治疗14 d为1个疗程。患者分别于治疗前与治疗1个疗程后进行评分测定。结果丁苯酞治疗组,依达拉奉治疗组以及联合治疗组CSS评分明显低于对照组,差异具有统计学意义(P0.05),其中联合治疗组CSS评分又明显低于丁苯酞治疗组和依达拉奉治疗组,差异具有统计学意义(P0.05)。而在Barthel指数测评上,对照组指数最低,丁苯酞治疗组及依达拉奉治疗组指数居中,联合治疗组指数最高,且对照组与其他三组比较差异具有统计学意义(P0.05),联合治疗组与丁苯酞组、依达拉奉组比较差异也具有统计学意义(P0.05)。苯酞治疗组和依达拉奉治疗组之间比较,差异不具有统计学意义(P0.05)。结论丁苯酞注射液联合依达拉奉对ACI患者神经功能恢复与生活能力的改善有显著作用。
[Abstract]:Objective to study the improvement of life ability in patients with acute cerebral infarction (ACI) treated with butyphthalide injection and Edaravone. Methods 120 patients with ACI were randomly divided into control group, butyphthalide treatment group, Edaravone treatment group and combined treatment group. 30 patients in each group were treated with ACI (aspirin, ozagrel, butylphthalide), and the Edaravone group received intravenous drip of Edaravone on the basis of control group. The combined treatment group was treated with butyphthalide and Edaravone on the basis of the control group, and compared the recovery status of nerve function among different groups by using the clinical neurological impairment scale (CSS) of stroke patients. The activity of daily living (ADL) was evaluated by Barthel index. The patients were treated for 14 days as a course of treatment. The patients were scored before and after one course of treatment. Results the patients in butyphthalide group were treated with butyrophthalide. The CSS score of Edaravone treatment group and combined treatment group was significantly lower than that of control group (P 0.05). The CSS score of combined treatment group was significantly lower than that of butyphthalide treatment group and Edaravone treatment group. The Barthel index of the control group was the lowest, the index of butyphthalide treatment group and Edaravone treatment group was the middle, and the combined treatment group had the highest index. The difference between the control group and the other three groups was statistically significant (P 0.05), and the difference between the combined treatment group and butyphthalide group and Edaravone group was also statistically significant (P 0.05), and between the phthalide treatment group and the Edaravone treatment group, there were significant differences between the two groups. Conclusion Butylphthalide injection combined with Edaravone has a significant effect on the recovery of nerve function and the improvement of life ability in patients with ACI.
【作者单位】：海南省保亭黎族苗族自治县人民医院内一科;海南省农垦总医院神经内科;
【分类号】：R743.33

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