胶质瘤瘤周水肿相关因素研究及临床意义

发布时间：2018-03-04 21:37

本文选题：胶质瘤　切入点：瘤周水肿　出处：《兰州大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：从临床表现、影像学、术中所见及病理学的角度研究影响胶质瘤瘤周水肿(PTBE)的因素,探讨胶质瘤瘤周水肿的临床意义。方法：收集65例首发胶质瘤患者的病历资料,头颅MRI、病理学资料,根据核磁共振资料计算获得瘤周水肿指数(EI),术中记录肿瘤质地和血供。分别研究临床表现、肿瘤部位、体积、术中情况及病理类型对PTBE发生率及EI的影响。结果：1.胶质瘤瘤周水肿EI与性别、年龄及患者症状持续时间无相关关系(P0.05)；EI与入院KPS评分呈负相关关系(相关系数为-0.440)。2.EI与肿瘤质地无关(P0.05),与肿瘤血供相关(P0.05)。3.不同部位的胶质瘤EI值有显著差异性(P0.05)。4.EI与肿瘤大小呈负相关关系(相关系数为-0.514)。5.EI与肿瘤病理类型无关(P0.05),但与病理级别和Ki-67阳性细胞检出率相关(P0.05)。结论：胶质瘤瘤周水肿程度与临床症状轻重、肿瘤部位、大小、血供、病理级别及恶性程度有关,与性别、年龄、症状持续时间、肿瘤质地及病理类型无关。
[Abstract]:Objective: to study the factors affecting PTBEs in the clinical manifestations, imaging, intraoperative findings and pathology, and to explore the clinical significance of peritumoral edema of gliomas. Methods: the medical records, head MRI and pathological data of 65 patients with first-episode glioma were collected. According to the MRI data, the peri-tumor edema index (EI) was obtained, and the tumor texture and blood supply were recorded during the operation. The effect of volume, intraoperative condition and pathological type on the incidence and ei of PTBE. Results 1. Ei and sex of peritumoral edema in gliomas, There was no correlation between age and duration of symptoms. There was a negative correlation between P0.05E and admission KPS score (correlation coefficient was -0.440? 2.EI was not correlated with tumor texture (P 0.05), and there was significant difference between ei value of glioma and tumor blood supply (P0.05. 4. Ei) and tumor blood supply. There was a negative correlation between tumor size and tumor size (the correlation coefficient was -0.514). 5. Ei was not related to the pathological type of the tumor (P 0.05), but to the pathological grade and the detection rate of Ki-67 positive cells (P 0.05). Conclusion: the degree of peritumoral edema is related to clinical symptoms, tumor location, size, blood supply, pathological grade and malignancy, but not to sex, age, duration of symptoms, tumor texture and pathological type.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.41

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