醋酸艾司利卡西平添加治疗成人难治性癫痫部分性发作有效性与安全性的Meta分析

发布时间：2018-03-05 18:14

本文选题：癫痫　切入点：部分性　出处：《中国全科医学》2016年08期 　论文类型：期刊论文

【摘要】：目的评价醋酸艾司利卡西平(ESL)添加治疗成人难治性癫痫部分性发作的有效性与安全性。方法计算机检索Cochrane图书馆、Pub Med、EMBase、OVID、CNKI、万方等电子数据库,筛选ESL治疗成人难治性癫痫部分性发作的所有随机对照试验(RCT),由2位独立的研究者提取资料并进行质量评价后,采用Rev Man 5.3软件进行Meta分析。结果共纳入5篇RCT,1 796例患者。ESL组的癫痫完全不发作率、发作频率减少≥50%的患者百分率高于安慰剂组〔RR=2.94,95%CI(1.76,4.89),P0.000 1;RR=1.77,95%CI(1.50,2.07),P0.000 01〕;ESL主要不良反应有头晕、嗜睡、头痛、呕吐等。但与安慰剂组相比,ESL 3个剂量组总的不良反应发生率均高于安慰剂组(P0.05)。结论每日800 mg或1 200 mg ESL添加治疗成人难治性癫痫能有效减少癫痫发作频率,不良反应可耐受。受文献数量、质量及疗程限制,上述结论还需更多多中心临床试验进一步验证。
[Abstract]:Objective to evaluate the efficacy and safety of ESL) in the treatment of intractable partial seizure in adults. Methods the electronic database of Cochrane Library was searched by computer. After screening all randomized controlled trials of ESL for the treatment of intractable partial seizures in adults, the data were extracted and evaluated by two independent researchers. Meta analysis was carried out with Rev Man 5.3 software. Results the incidence of complete seizure in 1 796 patients. The percentage of patients whose seizure frequency decreased more than 50% was higher than that in the placebo group. The main adverse reactions were dizziness, drowsiness, headache, headache. Compared with placebo group, the incidence of adverse reactions in the three dose groups was higher than that in the placebo group (P 0.05). Conclusion 800 mg or 1 200 mg ESL supplementation can effectively reduce the frequency of epileptic seizure in adult patients with intractable epilepsy. Adverse reactions are tolerable. Due to the quantity, quality and duration of the literature, these conclusions need to be further validated in more central clinical trials.
【作者单位】：四川医科大学药学院;泸州医学院附属医院;
【分类号】：R742.1

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