鼠神经生长因子联合血栓通对急性脑梗死患者血清TNF-α、sIL-2R、脂联素、C反应蛋白及神经功能评分的影响

发布时间：2018-03-05 22:10

本文选题：鼠神经生长因子　切入点：血栓通　出处：《中国老年学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的探讨鼠神经生长因子联合血栓通对急性脑梗死患者血清肿瘤坏死因子(TNF)-α、可溶性白细胞介素-2受体(s IL-2R)、脂联素、C反应蛋白(CRP)及神经功能评分的影响。方法 82例急性脑梗死患者根据入院顺序分为观察组和对照组各41例。对照组使用常规方案和血栓通治疗,观察组在此基础上加以鼠神经生长因子治疗。比较两组日常生活能力(ADL)和神经功能评分、临床疗效、血清TNF-α、s IL-2R、脂联素、CRP水平。结果治疗前,两组ADL评分和神经功能评分比较无显著差异(P0.05),治疗后,两组ADL评分显著升高,且观察组高于对照组,神经功能评分显著降低,且观察组低于对照组(均P0.05)。治疗后,观察组临床总有效率显著高于对照组(P0.05)。治疗前,两组血清TNF-α、s LR-2R、脂联素、CRP水平比较无显著差异(P0.05),治疗后,两组TNF-α、s LR-2R、CRP水平显著降低,且观察组低于对照组,脂联素水平显著升高,且观察组高于对照组(均P0.05)。结论鼠神经生长因子联合血栓通能明显降低急性脑梗死患者血清TNF-α、s IL-2R、CRP水平,并能升高脂联素水平,对神经功能发挥着明显的改善性作用,临床疗效显著。
[Abstract]:Objective to investigate the effects of nerve growth factor (NGF) combined with Xueshuantong (XT) on serum TNF- 伪, soluble interleukin-2 receptor (SIL-2RN), adiponectin C reactive protein (CRPP) and neurological function score in patients with acute cerebral infarction. According to the order of admission, patients with acute cerebral infarction were divided into observation group (n = 41) and control group (n = 41). The observation group was treated with nerve growth factor (NGF) on this basis. ADL), neurological function score, clinical efficacy, serum TNF- 伪 -sIL-2R and adiponectin CRP levels were compared between the two groups. There was no significant difference in ADL scores and neurological function scores between the two groups (P 0.05). After treatment, the ADL scores of the two groups were significantly increased, and those of the observation group were significantly higher than those of the control group, and the neurological function scores were significantly lower in the observation group than in the control group (P 0.05). The total effective rate in the observation group was significantly higher than that in the control group (P 0.05). Before treatment, there was no significant difference between the two groups in the levels of serum TNF- 伪 titers LR-2Rand adiponectin and CRP. After treatment, the levels of TNF- 伪 -LR-2Rn-CRP in the two groups were significantly decreased, and the levels of adiponectin in the observation group were significantly higher than those in the control group. Conclusion nerve growth factor combined with Xueshuantong can significantly decrease the serum TNF- 伪 -sIL-2RU CRP level and increase the adiponectin level in the patients with acute cerebral infarction, and play a significant role in improving the nervous function of the patients with acute cerebral infarction, and the observation group is higher than that of the control group (all P 0.05). The clinical effect is remarkable.
【作者单位】：凉山州第一人民医院神经外科;
【分类号】：R743.33

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