解痉合剂联合盐酸替扎尼定片治疗中风后痉挛性偏瘫（阴虚风动型）的疗效评价

发布时间：2018-03-09 00:18

本文选题：中风后痉挛性偏瘫　切入点：解痉合剂　出处：《浙江中医药大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：本课题通过临床研究,观察解痉合剂联合盐酸替扎尼定片治疗中风后痉挛性偏瘫的临床治疗效果,为治疗本病提供有效安全新方法。方法：按照纳入标准选择中风后痉挛性偏瘫患者110例,根据随机数字表法分为治疗组 1治疗组2治疗组3,3组均给予常规的神经内科及康复科治疗；治疗组1：给予加用盐酸替扎尼定片,同时每天用解痉合剂内服外用。治疗组2：给予加用盐酸替扎尼定片。治疗组3：给予加用解痉合剂内服外用。解痉合剂成分及用法：生白芍20克,炙甘草 10克,望江南20克,木瓜15克,乳香6克,没药6克,全蝎3克,丹参15克等；所用中药均为标准汤剂200毫升。服用方法：每日1剂,分早晚两次口服,同时用上方浸入500毫升的黄酒(酒精度13%v/v)中泡5天后再加热煎取药液300毫升做为外用药液 (由本院药剂科统一制作)涂擦痉挛肌群每日2次；盐酸替扎尼定片用法：2mg/次,3 次/日,每3天增加2mg,增加至4mg/次,3次/日维持治疗。在治疗前及治疗4周后对入组患者进行改良Ashworth评分、Barthel指数评分、Fugl-Meyer评分,评分由研究人员及康复治疗师共同进行。研究人员对资料进行收集、记录、保存和分析,贯彻单盲原则。结果：1.经治疗1个疗程后,经配对t检验,与同组治疗前相比,三组治疗后肢体肌张力、日常生活能力及运动功能都有显著的统计学意义(P0.05)。2.在改良Ashworth评分、Barthel指数评分、Fugl-Meyer评分上经方差分析进行两两比较,治疗组1与治疗组2比较P0.05,差异有显著统计学意义；治疗组1与治疗组3比较P0.05,差异有显著统计学意义；治疗组2与治疗组3比较P0.05,差异无统计学意义。结论：解痉合剂联合盐酸替扎尼定片治疗中风后痉挛性偏瘫的临床疗效优于单独使用解痉合剂或者盐酸替扎尼定片。
[Abstract]:Objective: this topic through clinical research, observation of spastic hemiplegia after stroke treated with Tizanidine Hydrochloride Tablets spasmolytic mixture
To provide effective and safe method for treating this disease. Methods: according to the inclusion criteria, 110 patients with spastic hemiplegia after stroke were selected and divided into treatment group according to random number table.
1 in the treatment group 2 treatment group 3,3 group were given routine treatment and rehabilitation; treatment group 1: to increase the use of salt
Acid tizanidine tablets, and antispasmodics oral topical treatment group: 2. Use every day to increase the use of Tizanidine Hydrochloride Tablets.
The treatment group: 3 to increase the use of internal and external components and antispasmodics. Usage: antispasmodics TGP 20 grams Zhigancao.
Wang Jiangnan 10 grams, 20 grams, papaya 15 grams, 6 grams of frankincense, myrrh 6 grams, 3 grams of scorpion, Salvia 15 grams; the
Use Chinese medicine as the standard decoction of 200 milliliters. Take the method: 1 doses per day, two times in the morning and evening, two times, at the same time soaked with the upper part of the decoction.
In 500 milliliters of yellow wine (alcohol 13%v/v) after 5 days, reheating and decocting 300 milliliters for external use
(Department of pharmacy of our hospital made uniform) with spastic muscles 2 times a day; Tizanidine Hydrochloride Tablets usage: 2mg/, 3
Every 3 days, the increase of 2mg, increased to 4mg/, and 3 / day maintenance treatment. Before and after 4 weeks of treatment,
The improved Ashworth score, the Barthel index score, the Fugl-Meyer score, and the score of the patients were studied.
The staff and rehabilitative therapists work together. The researchers collect, record, preserve and analyze the data and carry out single blindness.
Results: 1. after 1 courses of treatment, the three groups were treated with paired t test, compared with the same group before treatment.
There were significant statistical significance (P0.05).2. in the improved Ashworth evaluation.
The score of the Barthel index and the Fugl-Meyer score were compared by the analysis of variance 22. The treatment group was 1 and the treatment was treated.
Group 2 compared P0.05, the difference has significant statistical significance, 1 in the treatment group and 3 in the treatment group, P0.05, there is a difference between the treatment group and the treatment group 3.
Statistical significance; treatment group 2 and treatment group 3 compared to P0.05, the difference was not statistically significant. Conclusion: the combined treatment of Tizanidine Hydrochloride Tablets spasmolytic mixture after stroke clinical curative effect of spastic hemiplegia alone solution
As agent or Tizanidine Hydrochloride Tablets.

【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

【参考文献】