CT灌注成像对脑梗塞的应用研究

发布时间：2018-03-10 00:32

本文选题：CT灌注　切入点：脑梗塞　出处：《世界最新医学信息文摘》2016年90期 　论文类型：期刊论文

【摘要】：目的 CT灌注成像作为一种功能性成像方法,能够显示血流动力学改变,具有定量分析、诊断快速、无创的特点。本实验探讨64排CT脑灌注成像在急性缺血性脑血管疾病患者中的应用和临床意义,并分析CT灌注成像中参数CBF、CBV、TTP、MTT的诊断价值。方法选取扎兰屯市中蒙医院2013年1月至2015年2月期间脑梗塞(发病时间8小时)8例,男性5例,女性3例,年龄61.00±4.54(53~66)岁。CT灌注前均签署知情同意书。入院就诊时行CT灌注成像检查,记录相应患者灌注成像参数:CBF、CBV、TTP、及MTT,以其灌注异常区与镜像区正常脑组织分别作为病理组和对照组。结果 8例脑梗塞患者CT灌注成像均显示异常,其中2例发现缺血性半暗带。对6例CT灌注四个参数采用配对t检验进行统计分析,CBF、TTP及MTT比值差异有统计学意义,而CBV比值差异无统计学意义。2例显示缺血性半暗带患者梗死核心区、半暗带区与健侧对照均有明显改变。结论 (1)64排CT脑灌注成像急性脑梗塞患者可明确诊断病变部位、范围及判断脑梗塞患者有无缺血性半暗带的存在。(2)CBF、CBV、TTP、MTT的变化,可为临床诊断和治疗缺血性脑血管病提供病变区的血流动力学改变,可间接反映缺血部位的病理生理学状态。
[Abstract]:Objective as a functional imaging method, CT perfusion imaging can display hemodynamic changes, and has the advantages of quantitative analysis and rapid diagnosis. The purpose of this study was to investigate the application and clinical significance of 64-slice CT perfusion imaging in patients with acute ischemic cerebrovascular diseases. The diagnostic value of CBFV TTPMTT in CT perfusion imaging was analyzed. Methods from January 2013 to February 2015, 8 patients with cerebral infarction (5 males and 3 females) were selected from Zhongmeng Hospital, Zhalantun City. Age 61.00 卤4.54 ~ 5366). Prior to CT perfusion, informed consent was signed. Ct perfusion imaging was performed at admission. The perfusion imaging parameters: CBFV TTP and MTT were recorded. The normal brain tissue in the abnormal perfusion area and the mirrored area were used as the pathological group and the control group respectively. Results CT perfusion imaging of 8 patients with cerebral infarction showed abnormal perfusion imaging. Among them, ischemic penumbra was found in 2 cases. Statistical analysis was performed on the four parameters of CT perfusion in 6 cases by paired t test. There were significant differences in TTP and MTT ratio between CT perfusion and CT perfusion. However, there was no significant difference in CBV ratio between ischemic penumbra and ischemic penumbra. Conclusion the location of cerebral infarction can be clearly diagnosed in patients with acute cerebral infarction by CT perfusion imaging. The range and evaluation of the presence of ischemic penumbra in patients with cerebral infarction. The changes of TTPMTT can provide hemodynamic changes in the lesion area for clinical diagnosis and treatment of ischemic cerebrovascular disease, and can indirectly reflect the pathophysiological state of the ischemic site.
【作者单位】：内蒙古扎兰屯市中蒙医院;
【分类号】：R743.33

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