促红细胞生成素治疗HIE的临床疗效及对血清MMP-9、IL-6和TNF-α水平的影响

发布时间：2018-03-10 05:02

本文选题：促红细胞生成素　切入点：缺氧缺血性脑病　出处：《免疫学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨促红细胞生成素治疗HIE的临床疗效及对血清MMP-9、IL-6和TNF-α水平的影响。方法选择2012年8月至2016年7月我院治疗的缺氧缺血性脑病患者116例为研究对象,以抛硬币法将其分为对照组56例,观察组60例,且给予对照组患者常规治疗,而观察组则使用促红细胞生成素进行治疗,随后将2组的临床症状进行比较分析。结果观察组患者的总有效率(91.7%)明显大于对照组的总有效率(75.0%);治疗前后2组患者血清中的MMP-9、IL-6及TNF-α水平比较,观察组患者治疗后血清中MMP-9、IL-6及TNF-α值的降低幅度明显大于对照组;且MMP-9下降最早,观察组患者治疗后除阻力指数(resistance index,RI)外,其收缩期峰值流速(peak systolic flow velocity,PSFV)和舒张末期流速(end-diastolic flow velocity,EDFV)均明显高于对照组,2组比较差异明显,具有统计学意义(P0.05)。结论促红细胞生成素在治疗新生儿缺氧缺血性脑病方面的临床效果显著,MMP-9、IL-6及TNF-α的水平变化对缺氧缺血性脑病的早期诊断及预后有着重要指导意义。
[Abstract]:Objective to investigate the clinical efficacy of erythropoietin in the treatment of HIE and its effect on serum MMP-9 IL-6 and TNF- 伪 levels. Methods 116 patients with hypoxic ischemic encephalopathy (HIE) treated in our hospital from August 2012 to July 2016 were selected as subjects. It was divided into control group (56 cases), observation group (60 cases) and control group (60 cases) by the method of coin toss. The patients in the observation group were treated with erythropoietin, and the patients in the control group were treated with routine therapy. The clinical symptoms of the two groups were compared and analyzed. Results the total effective rate of the patients in the observation group was 91.7%, which was significantly higher than that in the control group (75.0%), and the levels of MMP-9 IL-6 and TNF- 伪 in the serum of the two groups were compared before and after treatment. The serum levels of MMP-9, IL-6 and TNF- 伪 in the observation group were significantly lower than those in the control group, and the MMP-9 was the first in the observation group, except for resistance index and index index after treatment in the observation group. The peak systolic flow velocityv and end-diastolic flow velocityv were significantly higher than those in the control group. Conclusion the clinical effect of erythropoietin in the treatment of neonatal hypoxic-ischemic encephalopathy is significant. The changes of MMP-9, IL-6 and TNF- 伪 are important for the early diagnosis and prognosis of hypoxic-ischemic encephalopathy.
【作者单位】：四川省医学科学院四川省人民医院儿科;
【分类号】：R742

【参考文献】