髓样细胞触发受体样转录因子-1与急性脑梗死的相关研究

发布时间：2018-03-10 23:10

本文选题：脑梗死　切入点：TLT-　出处：《中风与神经疾病杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的通过检测血小板表面髓样细胞触发受体样转录因子-1(Triggering receptor expressed on myeloid cells-like transcript 1,TLT-1)在急性脑梗死(acute cerebral infarction,ACI)患者的表达水平,探讨其与急性脑梗死的关系。方法采用流式细胞术(flow cytometry,FCM)检测脑梗死组与对照组髓样细胞触发受体样转录因子-1的表达水平,并进行相关分析。结果脑梗死组髓样细胞触发受体样转录因子-1的表达水平明显高于对照组(P0.01);且与脑梗死的病情严重程度和病灶大小呈正相关(r=0.656,P0.01;r=0.593,P0.01)。Logistic回归分析显示髓样细胞触发受体样转录因子-1是急性脑梗死发病的独立危险因素(OR值=1.155,95%CI 1.105~1.207,P0.01)。结论髓样细胞触发受体样转录因子-1可能是预测脑梗死的发病风险、评估病情严重程度和预后的生物指标。
[Abstract]:Objective to investigate the expression of receptor expressed on myeloid cells-like transcript 1 (TLT-1) in acute cerebral infarction (ACI) patients with acute cerebral infarction (ACI) by detecting the expression of platelet surface myeloid cell trigger receptor transcription factor-1 receptor on myeloid cells-like transcript 1 (TLT-1) in patients with acute cerebral infarction (ACI). Methods flow cytometry (FCM) was used to detect the expression of myeloid cell trigger receptor like transcription factor-1 in cerebral infarction group and control group. Results the expression level of myeloid cell trigger receptor-like transcription factor-1 in cerebral infarction group was significantly higher than that in control group (P 0.01), and was positively correlated with the severity of cerebral infarction and the lesion size. Like cell trigger receptor-like transcription factor-1 is an independent risk factor for acute cerebral infarction. The OR value of CI 1.105 ~ 1.207 (P0.01) is 1.155. Conclusion Myeloid cell triggered receptor-like transcription factor -1 may be a predictor of the risk of cerebral infarction. A biomarker to assess the severity and prognosis of the disease.
【作者单位】：内蒙古科技大学包头医学院第一附属医院神经内科;
【基金】：内蒙古科技大学包头医学院第一附属医院科学研究基金资助(BYJJ-QM 2016107)
【分类号】：R743.33

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