普罗布考对脑梗塞进展期患者APTT、纤维蛋白原及血液流变学的影响

发布时间：2018-03-11 05:16

本文选题：普罗布考　切入点：脑梗塞　出处：《中国现代医学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨普罗布考治疗对脑梗塞进展期患者活化部分凝血活酶时间(APTT)、纤维蛋白原及血液流变学的影响,为普罗布考治疗脑梗塞的临床应用提供依据。方法选取2014年1月-2015年1月该院神经内科收治的80例脑梗塞进展期患者为研究对象,随机分为研究组和对照组,每组40例,对照组采取常规药物治疗,研究组在对照组基础上加用普罗布考,比较两组患者治疗前后的APTT、纤维蛋白原及血液流变学的变化。结果研究组的疗效与对照组比较,差异统计学意义(P0.05)。研究组患者治疗后APTT较治疗前延长,且治疗后30 d时间较治疗后15 d延长。研究组患者治疗后APTT与对照组比较,差异有统计学意义(P0.05)。研究组患者治疗后纤维蛋白原水平较治疗前降低,且治疗后30 d水平低于治疗后15 d;研究组患者治疗后的纤维蛋白原水平与对照组比较,差异有统计学意义(P0.05)。研究组患者治疗后的血浆黏度、全血高切黏度及全血低切黏度较治疗前均降低,且治疗后30 d较治疗后15 d降低;研究组患者治疗后血浆黏度、全血高切黏度及全血低切黏度与对照组比较,差异有统计学意义(P0.05)。结论普罗布考治疗脑梗塞进展期患者疗效显著,能够延长APTT,降低纤维蛋白原水平,降低血浆黏度、全血高切黏度及全血低切黏度,值得推广应用。
[Abstract]:Objective to investigate the effect of probucol treatment on cerebral infarction patients with advanced activated partial thromboplastin time (APTT), effects of fibrinogen and blood rheology, provide the basis for clinical application of probucol in treatment of cerebral infarction. Methods from January 2014 -2015 year in January the hospital neurology department treated 80 cases of cerebral infarction patients in advanced stage the object of study, were randomly divided into study group and control group, 40 cases in each group, the control group take routine treatment, the study group compared with the control group were treated with probucol, two groups were compared before and after treatment of APTT, the changes of fibrinogen and blood rheology. Results the study group compared with the control group, the difference was statistically significant (P0.05). To extend the study group after treatment in patients with APTT compared with those before treatment, and the treatment time is 30 d after 15 d after treatment. The study group prolonged after treatment in patients with APTT compared with the control group, the difference was statistically significant (P 0.05). Study on fibrinogen levels than patients in the treatment group after treatment decreased below 30 d and after treatment with 15 d after treatment; group of patients in the study group after treatment of fibrinogen level with the control, the difference was statistically significant (P0.05). The blood viscosity groups after treatment, whole blood high the viscosity and blood viscosity were decreased significantly compared with before treatment, after treatment and 30 d compared to 15 d after treatment decreased; study group patients after plasma viscosity, whole blood viscosity and group compared with the control of blood viscosity, the difference was statistically significant (P0.05). Conclusion probucol treatment in patients with advanced cerebral infarction curative effect obviously, can prolong APTT, reducing the level of fibrinogen, reduce plasma viscosity, whole blood viscosity and blood viscosity, it is worthy of popularization and application.

【作者单位】：西南医科大学附属医院药剂科;
【分类号】：R743.33

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