帕金森病患者相关生化水平的临床研究

发布时间：2018-03-13 10:37

本文选题：帕金森病　切入点：血脂　出处：《实用医学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨帕金森病患者相关生化水平与疾病等级、病程的关系。方法:测定69例确诊为帕金森病患者(PD组)以及69例性别、年龄相匹配的健康成人(对照组)的尿酸和血脂水平,并进行统计学分析。结果:PD组血尿酸、三酰甘油、总胆固醇、低密度脂蛋白(LDL-C)水平分别为(322.48±66.18)μmol/L、(1.22±0.86)mmol/L、(4.70±0.92)mmol/L、(3.00±0.85)mmol/L,而对照组分别为(384.23±88.28)μmol/L、(1.64±0.94)mmol/L、(5.37±1.31)mmol/L、(3.53±1.03)mmol/L,两组分别比较,差异均具有统计学意义(t=-4.68,P=0.000;t=-2.74,P=0.007;t=-2.74,P=0.007;t=-3.49,P=0.001;t=-3.27,P=0.001)。PD组中病程3年者的血尿酸LDL-C水平显著低于病程≤3年者(t=3.373,P=0.001;t=2.440,P=0.017)。Hoehn-Yahr分期中,各期PD患者血尿酸水平均低于对照组(P0.05);早、中期PD患者各类血脂水平均明显低于对照组(P0.05);女性PD患者血尿酸、总胆固醇、高密度脂蛋白(HDL-C)分别为(305.69±54.25)μmol/L、(4.99±0.95)mmol/L、(1.25±0.27)mmol/L,男性PD患者为(339.76±73.40)μmol/L,(4.41±0.81)mmol/L、(1.06±0.19)mmol/L,男、女患者间分别进行比较,差异均具有统计学意义(t=2.198,P=0.031;t=-2.721,P=0.008;t=-3.266,P=0.002)。Logistic回归示低血尿酸水平是PD发病的危险因素(OR=1.01,95%CI 1.004~1.015,P=0.001)。结论:PD患者生化水平存在多种改变,尿酸降低可能是帕金森病的危险因素之一。
[Abstract]:Objective: to investigate the relationship between biochemical level and disease grade and course of Parkinson's disease. Methods: 69 patients with Parkinson's disease (PD) and 69 patients with Parkinson's disease (PD) and gender were measured. Uric acid and blood lipid levels in age-matched healthy adults (control group) were analyzed statistically. Results Blood uric acid, triglyceride, total cholesterol, The LDL-C levels of LDL-C were 322.48 卤66.18 渭 mol / L, 1.22 卤0.86 mmol / L, 4.70 卤0.92 mmol / L, respectively, while those in the control group were 384.23 卤88.28 渭 mol / L, 1.64 卤0.94mmol / L 5.37 卤1.31 mmol / L, 3.53 卤1.03mmol / L, respectively. The difference between the two groups was statistically significant. Serum uric acid levels in PD patients in all stages were significantly lower than those in controls (P 0.05); in early and middle stage PD patients were significantly lower than those in controls (P 0.05); in female PD patients, uric acid, total cholesterol and HDL-C were 305.69 卤54.25) 渭 mol 路L ~ (-1) 路L ~ (-1) 卤0.95 mmol 路L ~ (-1) 卤0.27 mmol 路L ~ (-1) respectively, and in male PD patients were 339.76 卤73.40 渭 mol / L, 4.41 卤0.81mmol / L, 1.06 卤0.19 mmol / L / L, respectively, male, and male, P / L = 1.06 卤0.19 mmol / L / L = 1.06 卤0.19 mmol / L / L = 1.06 卤0.19 mmol / L / L = 1.06 卤0.19 mmol / L / L = 1.06 卤0.19 mmol / L / L, respectively. The difference was statistically significant among the female patients. The differences were statistically significant. Conclusion there are many changes in biochemical level in patients with PD, and the decrease of uric acid may be one of the risk factors of Parkinson's disease, and the decrease of uric acid may be one of the risk factors of Parkinson's disease.
【作者单位】：广州医科大学附属第二医院神经内科;
【分类号】：R742.5

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