活血化瘀解郁方治疗气滞血瘀型脑卒中后抑郁的临床疗效观察

发布时间：2018-03-14 06:06

本文选题：脑卒中后抑郁　切入点：活血化瘀解郁　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察活血化瘀解郁方治疗气滞血瘀型脑卒中后抑郁(Post-stroke depression,PSD)患者的临床疗效。方法:选取60例气滞血瘀型脑卒中后抑郁患者作为研究对象,按就诊顺序随机分配治疗组与对照组。中药治疗组及对照组各30例,部分入组病例在研究期间出现脱落,最终治疗组27例、对照组26例。治疗组予活血化瘀解郁方加口服草酸艾司西酞普兰片(来士普)治疗(中药每日一贴,分早、晚二次温水冲服,草酸艾司西酞普兰片,1Omg 1/早);对照组口服草酸艾司西酞普兰片,1Omg 1/早治疗。两组患者均给予神经内科脑血管病常规治疗。两组疗程均6周。于治疗前、治疗2周、4周及6周时,分别对两组患者进行汉密尔顿抑郁量表(HAMD)评分,美国国立卫生研究院神经功能缺损量表(NIHSS)评分、Barthel指数评分及中医症候评分。治疗组与对照组比较,同时在临床实验期间进行常规安全性检查,评价活血化瘀解郁方治疗气滞血瘀型脑卒中后抑郁的临床治疗效果及用药安全性。结果:治疗组在降低汉密尔顿抑郁量表(HAMD)评分,神经功能缺损量表(NIHSS)评分及中医症候评分,提高Barthel指数评分均明显优于对照组,差异有统计学意义(P0.05)。对不良反应的观察,两组患者均未出现严重不良反应,提示本方运用于临床治疗脑卒中后抑郁是安全的。结论:活血化瘀解郁方治疗气滞血瘀型脑卒中后抑郁,疗效确切,不仅能显著改善患者抑郁症状,并且可以促进患者神经功能缺损的恢复,提高患者独立生活能力,且无不良反应,安全有效。
[Abstract]:Objective: to observe the clinical effect of Huoxue Huayu Jieyu recipe in treating post stroke depression of qi stagnation and blood stasis type. Methods: 60 patients with post stroke depression of qi stagnation and blood stasis type were selected as study objects. The treatment group and the control group were randomly assigned according to the order of visit. 30 cases each in the traditional Chinese medicine treatment group and 30 cases in the control group, some of the cases in the group fell off during the study period, and 27 cases in the final treatment group, In the control group, 26 cases were treated with Huoxue Huayu Jieyu decoction plus oral estalopram oxalate (Lestopram). Oxalcitalopram oxalate (1Omg / L) and control group (control group) were treated orally with oxalcitalopram (1Omg / L). The patients in both groups were given routine treatment of cerebrovascular diseases in neurology department. The course of treatment in both groups was 6 weeks. Before and after treatment, the patients were treated for 2 weeks, 4 weeks and 6 weeks, respectively. Two groups of patients were evaluated with Hamilton Depression scale (Hamd), National Institutes of Health (NIH) Neurologic deficit scale (NIHSS), Barthel Index (BI) and TCM symptom scale (TCM). At the same time, routine safety examination was carried out during the clinical trial to evaluate the efficacy and safety of Huoxue Huayu Jieyu recipe in the treatment of post-stroke depression of Qi stagnation and Blood stasis type. Results: the treatment group was reducing the score of Hamilton Depression scale (Hamd). The scores of neurological deficit scale (NDS) and TCM symptoms, and the scores of improving Barthel index were significantly better than those of the control group (P 0.05). No serious adverse reactions were found in the two groups. Conclusion: Huoxue Huayu Jieyu prescription is effective in treating post-stroke depression of Qi stagnation and Blood stasis type. It can promote the recovery of neurological deficit, improve the independent living ability of patients, no adverse reactions, safe and effective.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3;R749.4

【参考文献】