帕金森病运动并发症危险因素回顾性研究

发布时间：2018-03-16 11:49

  本文选题：帕金森病　切入点：左旋多巴　出处：《福建医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：对长期服用左旋多巴引起运动并发症的PD患者进行评估，试图寻找与其相关的危险因素，并结合国内外已有的研究结果，分析相关因素的可能病理生理机制，以指导临床上预防和减少运动并发症的发生，提高PD患者的生活质量。 方法：对94例门诊确诊的原发性PD病人进行回顾性研究，收集内容包括：年龄、性别、起病年龄、病程、左旋多巴使用情况、合并抗帕金森病用药使用情况、吸烟、饮酒、喝茶、有毒物质接触史等生活习惯。所有数据使用SPSS21.0软件进行统计分析，采用t检验、Mann-Whitney U非参数检验、χ2检验、Fisher确切概率法进行组间差异比较；logistic回归分析得出危险因素；K-M生存曲线描述左旋多巴疗程与运动并发症发生的趋势。 结果：组间差异比较中发病年龄、病程、左旋多巴疗程、左旋多巴单日剂量、左旋多巴日均剂量、吸烟史与异动症的发生有关（P＜0.05）；病程、左旋多巴疗程、左旋多巴单日剂量、左旋多巴日均剂量与症状波动发生有关（P＜0.05）。异动症患者中低龄起病为独立危险因素；症状波动患者中，病程及左旋多巴日均剂量为独立危险因素。 结论：我们的研究结果表明，发病年龄是异动症发生的独立危险因素，发病年龄越小，越容易发生异动症；病程和左旋多巴日均剂量是症状波动发生的独立危险因素，病程越长、左旋多巴治疗剂量越大，越容易发生症状波动；生存曲线提示左旋多巴疗程长会增加运动并发症的发生率；控制症状、减少运动并发症发生十分重要，避免或减少接触危险因素，可提高PD患者生活质量，同时延长生存时间。
[Abstract]:Objective: to evaluate the risk factors of PD patients who take levodopa for a long time and analyze the possible pathophysiological mechanism of the related factors. In order to guide clinical prevention and reduce the occurrence of sports complications, improve the quality of life of PD patients. Methods: a retrospective study was conducted on 94 patients with primary PD diagnosed in outpatient department. The data included age, sex, onset age, course of disease, use of levodopa, drug use of anti-Parkinson 's disease, smoking and drinking. Drinking tea, history of exposure to toxic substances and other habits. All data are analyzed using SPSS21.0 software. T test and 蠂 2 test were used to compare the difference between groups. Logistic regression analysis showed that the survival curve of K-M was used to describe the trend of levodopa treatment and sports complications. Results: the age of onset, course of disease, course of treatment of levodopa, daily dose of levodopa, daily average dose of levodopa, smoking history were related to the occurrence of ADHD (P < 0.05), course of disease, course of treatment of levodopa, daily dose of levodopa. The mean daily dose of levodopa was related to the occurrence of symptomatic fluctuation (P < 0.05). In patients with dyskinesia, the onset of early onset was an independent risk factor, and the course of disease and the daily average dose of levodopa were independent risk factors in patients with symptomatic fluctuation. Conclusion: the age of onset is an independent risk factor for the occurrence of dyskinesia, and the younger the onset age, the more likely it is to develop dyskinesia, the course of disease and the daily average dose of levodopa are independent risk factors for the occurrence of symptoms. The longer the course of disease, the greater the dosage of levodopa, the more prone to symptoms fluctuation; the survival curve indicates that the long course of treatment of levodopa will increase the incidence of sports complications; it is very important to control symptoms and reduce the occurrence of sports complications. To avoid or reduce exposure to risk factors can improve the quality of life and prolong the survival time of PD patients.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5
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本文编号：1619785