大脑中动脉搏动指数与腔隙性脑梗死认知损害的相关性

发布时间：2018-03-16 23:27

本文选题：卒中　切入点：认知障碍　出处：《中国脑血管病杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨大脑中动脉搏动指数与腔隙性脑梗死患者认知功能障碍之间的关系,为卒中后认知功能障碍提供更多早期诊断方法。方法回顾性连续纳入2015年10月到2016年5月新疆军区总医院神经内科门诊及住院的急性腔隙性脑梗死患者60例为腔梗组,同期行脑血管功能检查无脑梗死的对照人群30例为对照组,所有患者进行基本信息采集及经颅多普勒超声检查,记录大脑中动脉搏动指数,同时采用事件相关电位P300、画钟测验、连线测验A和B评价两组患者认知功能并进行比较。结果腔梗组患者搏动指数较对照组增高(1.14±0.63比0.89±0.24),差异有统计学意义(P0.05);两组认知功能比较,腔梗组较对照组事件相关电位潜伏期延长[(351±34)ms比(321±15)ms]、波幅降低[(5.0±1.4)μV比(7.9±2.6)μV],连线测验A、B测试时间延长[(81±7)s比(64±8)s,(166±18)s比(105±25)s],差异均有统计学意义(均P0.05)。搏动指数与事件相关电位潜伏期和连线测验A、B测试时长呈正相关(r分别为0.517、0.393、0.637;均P0.05),与事件相关电位波幅呈负相关(r=-0.324,P=0.007)。结论大脑中动脉搏动指数与腔隙性脑梗死患者的认知功能损害有关,高搏动指数可提示一些认知域的障碍;经颅多普勒超声检查可视为卒中后早期诊断认知功能障碍的辅助工具之一。
[Abstract]:Objective to investigate the relationship between middle cerebral artery pulsatility index and cognitive impairment in patients with lacunar infarction. Methods from October 2015 to May 2016, 60 patients with acute lacunar cerebral infarction who were admitted to the Department of Neurology, Department of Neurology, Xinjiang military region General Hospital were included as the lumen infarction group. 30 cases of control group without cerebral infarction underwent cerebrovascular function examination at the same time. All the patients underwent basic information collection and transcranial Doppler ultrasound examination to record the pulsatile index of middle cerebral artery. At the same time, the event-related potential (P300) was used to draw the clock test. Results compared with the control group, the pulsatile index of the two groups was 1.14 卤0.63 vs 0.89 卤0.24, the difference was statistically significant (P 0.05), the cognitive function of the two groups was higher than that of the control group. Compared with the control group, the latency of event-related potential was prolonged [351 卤34 Ms vs 321 卤15 Ms], the amplitude decreased [5.0 卤1.4) 渭 V vs 7.9 卤2.6 渭 V], and the test time of Aneb was prolonged [81 卤7s vs 64 卤8s vs 166 卤18s vs 105 卤25s], the difference was statistically significant (P 0.05). The positive correlation r was 0.517 ~ 0.393 ~ 0.637, respectively, and there was a negative correlation with the amplitude of event-related potential. Conclusion the pulsatility index of middle cerebral artery is related to cognitive impairment in patients with lacunar cerebral infarction, and it is negatively correlated with the amplitude of event-related potential (P < 0.05), which is negatively correlated with the amplitude of event-related potentials. Conclusion there is a significant correlation between the pulsatile index of middle cerebral artery and the cognitive impairment in patients with lacunar cerebral infarction. The high pulsatility index may indicate some cognitive domain disorders, and transcranial Doppler ultrasound can be regarded as one of the auxiliary tools for the early diagnosis of cognitive dysfunction after stroke.
【作者单位】：新疆维吾尔自治区石河子大学医学院;新疆军区总医院心内科;新疆军区总医院神经内科;
【基金】：军队后勤科研计划(CLJ16J006)
【分类号】：R743.33

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