小胶质细胞特性及其功能的研究进展

发布时间：2018-03-19 10:47

本文选题：小胶质细胞　切入点：中枢神经系统　出处：《医学研究生学报》2017年02期 　论文类型：期刊论文

【摘要】：小胶质细胞广泛分布于中枢神经系统,是神经系统中发挥免疫功能的主要细胞,生理情况下起监视作用,稳定内环境,小胶质细胞对外界刺激非常敏感,一旦中枢神经系统发生轻微病理变化即可激活小胶质细胞,活化后的小胶质细胞一方面发挥吞噬作用,吞噬细胞碎片,分泌生长因子促进神经修复,另一方面也能分泌一些炎症因子、谷氨酸、一氧化氮等,加重炎症反应,引起继发损伤。文中将对小胶质细胞的特性及其在中枢神经系统疾病中的作用进行综述,为中枢神经系统疾病的治疗提供新靶点。
[Abstract]:Microglia, which are widely distributed in the central nervous system, are the main cells in the nervous system that play an immune function. Under physiological conditions, microglia play a monitoring role and stabilize the internal environment. Microglia are very sensitive to external stimuli. Once slight pathological changes occur in the central nervous system, microglia can be activated. On the one hand, activated microglia play a role in phagocytosis, phagocytic fragments, and secretion of growth factor to promote nerve repair. On the other hand, it can also secrete some inflammatory factors, such as glutamate, nitric oxide and so on, which aggravate the inflammatory reaction and cause secondary injury. This paper reviews the characteristics of microglia and its role in central nervous system diseases. To provide a new target for the treatment of central nervous system diseases.
【作者单位】：昆明医科大学第二附属医院中心实验室;昆明医科大学第二附属医院科教处;
【基金】：云南省科技计划项目-省应用基础研究(昆医联合专项)(2013FB150,2015FA006) 云南省教育厅科学研究项目基金(2014Z062) 昆明医科大学研究生创新基金(2016S26)
【分类号】：R741

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