脑血流动力学指标变化与脑血管老化关系

发布时间：2018-03-19 14:33

本文选题：血流动力学　切入点：脑血管病　出处：《中国公共卫生》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨脑血流动力学指标的年龄变化规律与血管老化的关系。方法选择2014年1—10月在中南大学湘雅第三医院、中国人民解放军180医院、山东电力中心医院、南华大学附属第二医院4个健康管理中心参加健康体检的人群作为研究对象,调查年龄、性别等一般情况,进行无创伤脑血流动力学检查。按年龄、性别分组,比较不同年龄组间脑血管功能积分值、平均流速、最小流速、脉搏波波速、外周阻力等指标的差异及变化规律。结果纳入研究对象共计29 931人,年龄范围20~94岁。男女脑血管功能积分值异常率(75分)分别为23.4%和21.2%,平均值分别为(82.18±23.65)和(84.33±22.05)分,差异均有统计学意义(P0.05)。随着年龄的增长,脑血管功能积分值、平均脑血流速度、最小脑血流速度呈明显的降低趋势,脉搏波波速、外周阻力呈明显的上升趋势,上述指标年龄组间的差异均有统计学意义(P0.05)。45岁和65岁年龄组是脑血管功能积分值降低幅度加大的拐点,65岁各年龄组脑血管功能积分值持续大幅度降低。结论脑血流动力学指标的异常变化与增龄密切相关,步入中年和老年,脑血管功能下降的幅度加大,65岁脑血管功能持续大幅下降。
[Abstract]:Objective to investigate the relationship between age change of cerebral hemodynamic parameters and aging of blood vessels. Methods from January to October, 2014, the third Xiangya Hospital of Central South University, 180 Hospital of Chinese people's Liberation Army, Shandong Electric Power Center Hospital were selected. Four health management centers of the second affiliated Hospital of South China University took part in health check-up as research objects, investigated age, sex, and other general conditions, and carried out non-traumatic cerebral hemodynamic tests, which were grouped by age and sex. The differences and changes of cerebrovascular function integral value, mean velocity, minimum velocity, pulse wave velocity and peripheral resistance among different age groups were compared. Results 29 931 subjects were included in the study. Age range 20 to 94 years old. The abnormal rate of cerebrovascular function integral value in male and female were 23.4% and 21.2 respectively, the average value was 82.18 卤23.65) and the average value was 84.33 卤22.05), the difference was statistically significant (P 0.05). With the increase of age, the integral value of cerebrovascular function and the average cerebral blood flow velocity were significant. The minimum cerebral blood flow velocity decreased obviously, the pulse wave velocity and the peripheral resistance showed an obvious upward trend. The difference of the above indexes among age groups was statistically significant (P 0.05). 45 years old and 65 years old group are the inflection point where the reduction of cerebrovascular function integral value is increased. Conclusion the cerebral blood function integral value of each age group of 65 years old continues to decrease significantly. The abnormal changes of hydrodynamic indexes are closely related to aging. In middle age and old age, cerebrovascular function decreases greatly in 65 years old.
【作者单位】：上海市脑血管病防治研究所;中南大学湘雅第三医院健康管理中心;中国人民解放军180医院健康管理中心;山东电力中心医院;南华大学附属第二医院健康管理中心;
【分类号】：R743.3

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