基质金属蛋白酶-9基因多态性与缺血性脑卒中的相关性

发布时间：2018-03-21 14:55

  本文选题：基质金属蛋白酶-　切入点：动脉粥样硬化　出处：《中国神经精神疾病杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨基质金属蛋白酶-9(matrix metalloproteinases-9,MMP-9)基因多态性与缺血性脑卒中的相关性。方法运用多重小测序技术(multiplex SNa Pshot)分析粤西地区251例缺血性脑卒中患者和96例健康对照组MMP-9基因(rs3787268、rs3918241、rs3918242)的多态性分布,并分析与缺血性脑卒中的相关性。结果 (1)与对照组相比,病例组rs3787268基因型频率有统计学差异(P=0.042),在隐性模型中A/A基因型的个体患病风险升高(OR=2.21,P=0.046);(2)rs3918242基因型频率亦有统计学差异(P=0.007),在显性模型中,携带T基因型的个体患病风险升高(OR=2.14,P=0.009);(3)其中rs3787268在大动脉粥样硬化(large artery atherosclerosis,LAA)亚型组的基因型分布与对照组相比有统计学差异(P=0.039),而非LAA亚型中无统计学差异;rs3918242在LAA亚型组的基因型和等位基因频率与对照组相比分别有统计学差异(P=0.009,P=0.047),在非LAA亚型中无统计学差异。结论 MMP-9基因rs3787268和rs3918242多态位点突变可能与中国粤西地区汉族人群缺血性脑卒中的发病风险相关;并主要可能增加了LAA型脑卒中的发病风险。
[Abstract]:Objective to investigate the expression of matrix metalloproteinase -9 (matrix metalloproteinases-9 MMP-9) gene polymorphism and ischemic stroke. Methods using multiple small sequencing technology (multiplex SNa Pshot) Yuexi area analysis of 251 patients with ischemic stroke and 96 healthy control group MMP-9 gene (rs3787268, rs3918241, rs3918242) polymorphism, and analysis correlation with cerebral ischemic stroke. Results (1) compared with the control group, the case group rs3787268 genotype had significant difference (P=0.042), the A/A genotype in the recessive model in individual risk increased (OR=2.21, P=0.046); (2) the frequency of rs3918242 genotype was also statistically difference (P=0.007), the dominant in the model, with T genotype increased risk (OR=2.14, P=0.009); (3) the rs3787268 (large artery atherosclerosis in large artery atherosclerosis subtype, LAA) gene group 鍒嗗竷涓庡�圭収缁勭浉姣旀湁缁熻�″�﹀樊寮�(P=0.039),鑰岄潪LAA浜氬瀷涓�鏃犵粺璁″�﹀樊寮，

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