脑白质疏松相关危险因素分析

发布时间：2018-03-21 18:43

本文选题：LA　切入点：危险因素　出处：《福建医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨脑白质疏松症(leukoaraiosis LA)相关危险因素。方法:对收治的164例LA患者（LA组）及104例非LA患者（非LA组）的性别、年龄、高血压、糖尿病、吸烟、饮酒、血脂异常、血浆纤维蛋白原、空腹血糖、D二聚体、尿酸、血清白蛋白、同型半胱氨酸等指标进行调查评估，对LA的相关危险因素进行分析。结果：LA组的患者患有糖尿病、高血压、吸烟、饮酒的比例明显比非LA组高（P0.05）；与非LA组相比，LA组尿酸（356.49±121.85vs289.96±102.98，P=0.000）、年龄（65.43±9.56vs52.77±7.05,p=0.000）、血浆纤维素原（3.28±0.84vs2.86±0.67，，p=0.000）、同型半胱氨酸（15.57±6.22vs12.74±4.93、p=0.000）、血清白蛋白(49.95±5.06vs43.52±3.61、p=0.006)、空腹血糖（5.79±2.87vs5.14±0.64、p=0.026）、高密度脂蛋白(1.19±0.41vs1.34±0.48、p=0.006）、低密度脂蛋白（2.95±1.06vs2.70±0.96、p=0.049）两组具有明显的统计学差异（P0.05）。经logistic多因素回归分析，高血压、年龄、Hcy、尿酸、血清白蛋白血与LA的发生独立相关。结论：说明高血压、年龄、Hcy、尿酸、血清白蛋白低是LA的独立危险因素。
[Abstract]:Objective: to investigate the risk factors of leukoaraiosis in leukoaraiosis. Methods: sex, age, hypertension, diabetes, smoking, alcohol consumption, dyslipidemia, plasma fibrinogen, fasting blood glucose D-dimer, uric acid were studied in 164 LA patients and 104 non-LA patients (non-LA group). Serum albumin and homocysteine were investigated and evaluated to analyze the risk factors of LA. Results the patients in the% LA group had diabetes, high blood pressure, smoking, Compared with the non-LA group, the ratio of drinking alcohol was significantly higher than that of the non-LA group (356.49 卤102.98 121.85vs289.96 卤102.98), the age was 65.43 卤7.05 9.56vs52.77 卤7.05, the plasma fibrinogen was 3.28 卤0.67p0.000, the homocysteine was 15.57 卤4.93, the serum albumin was 49.95 卤3.61, the fasting blood glucose was 5.79 卤0.64p0.026, the high density lipoprotein was 1.19 卤0.48pP, the low density lipoprotein was 2.95 卤1.06vs2.70 卤0.96p0.049). The statistical difference was significant (P 0.05). By logistic multivariate regression analysis, Hypertension, age, uric acid, serum albumin and LA were independently associated. Conclusion: hypertension, age, uric acid, serum albumin are independent risk factors of LA.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R744.5

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