颈动脉重度狭窄或闭塞导致脑梗死发病机制的研究

发布时间：2018-03-23 17:36

  本文选题：重度颈动脉颅外段狭窄或闭塞　切入点：急性脑梗死　出处：《中风与神经疾病杂志》2016年02期

【摘要】：目的探讨重度颈动脉颅外段(ICA)狭窄或闭塞患者急性脑梗死的发病机制。方法采用CDFI或TCD筛选75例颈动脉颅外段重度狭窄或闭塞导致的急性脑梗死患者,利用TCD检测脑梗死患者颅内血液动力学变化,采用乳胶增强免疫比浊法测量hs-CRP水平,根据MRI定位对脑梗死模式进行分类,分析颈动脉颅外段重度狭窄或闭塞与脑梗死模式的关系;分析血清hs-CRP水平与颈动脉不稳定斑块及脑梗死模式之间的相关性。结果 (1)区域梗死(Ⅰ型)和分水岭梗死(Ⅴ型)发生率较高,颈动脉颅外段重度狭窄或闭塞与脑梗死模式有关(P0.01)。(2)不稳定斑块组hs-CRP水平明显高于稳定斑块组(P0.01),hs-CRP水平与脑梗死模式之间无相关性(P0.05)。结论 (1)重度颈动脉颅外段狭窄的程度能影响脑梗死的模式,是急性脑梗死主要病因之一。(2)血清hs-CRP升高与脑梗死关系密切,是脑梗死的致病因子。
[Abstract]:Objective to investigate the pathogenesis of acute cerebral infarction in patients with severe stenosis or occlusion of extracranial carotid artery. Methods 75 patients with acute cerebral infarction caused by severe stenosis or occlusion of extracranial carotid artery were screened by CDFI or TCD. The changes of intracranial hemodynamics in patients with cerebral infarction were detected by TCD. The levels of hs-CRP were measured by latex enhanced immunoturbidimetry. The patterns of cerebral infarction were classified according to the location of MRI. To analyze the relationship between severe stenosis or occlusion of extracranial carotid artery and cerebral infarction model. The correlation between serum hs-CRP level and carotid artery unstable plaque and cerebral infarction pattern was analyzed. Results the incidence of regional infarction (type 鈪，

本文编号：1654484