甘露醇联合地塞米松对感染性脑水肿患者相关指标的影响

发布时间：2018-03-26 03:39

  本文选题：甘露醇　切入点：地塞米松　出处：《中国药房》2017年24期

【摘要】：目的:探讨甘露醇联合地塞米松对感染性脑水肿患者相关指标的影响。方法:回顾性分析120例感染性脑水肿患者资料,按治疗方案的不同分为对照组(60例)和观察组(60例)。对照组患者给予呋塞米注射液20 mg+20%甘露醇注射液1 g/(kg·次)+0.9%氯化钠注射液10 mL,静脉滴注,每6 h 1次,用药3 d后视患者病情调整剂量。观察组患者给予地塞米松磷酸钠注射液10～20 mg+20%甘露醇注射液1 g/(kg·次)+0.9%氯化钠注射液10 mL,静脉滴注,每6 h 1次,用药3 d后视患者病情调整剂量。两组均以7 d为1个疗程,共治疗2个疗程。观察两组患者治疗前后一氧化氮(NO)、白细胞介素1(IL-1)、肿瘤坏死因子α(TNF-α)水平,病死率、后遗症及不良反应发生情况。结果:治疗前,两组患者NO、IL-1、TNF-α水平比较,差异均无统计学意义(P0.05)。治疗后,两组患者NO、IL-1、TNF-α水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。观察组患者病死率、后遗症及不良反应发生率均显著低于对照组,差异均有统计学意义(P0.05)。结论:甘露醇联合地塞米松能降低感染性脑水肿患者的炎症因子水平、后遗症发生率及病死率,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of mannitol combined with dexamethasone on the related indexes in patients with infectious brain edema. The patients in the control group were given furosemide injection 20 mg 20% mannitol for 1 g/(kg) 0.9% sodium chloride injection 10 mL intravenous drip once every 6 h, and the control group was divided into two groups according to the different treatment schemes: control group (n = 60) and observation group (n = 60). The patients in the control group were given furosemide injection 20 mg 20% mannitol (1 g/(kg). The patients in the observation group were treated with dexamethasone sodium phosphate injection 10 ~ 20 mg 20% mannitol (1 g/(kg), 0.9% sodium chloride injection 10 mL, intravenous drip once every 6 h, after 3 days of treatment, the patients in the observation group were given dexamethasone sodium phosphate injection (10 mg 20% mannitol injection 1 g/(kg). The patients in both groups were treated with 7 days as a course of treatment for 2 courses of treatment. The levels of nitric oxide (no), interleukin 1 (IL 1), tumor necrosis factor 伪 (TNF- 伪), and mortality were observed before and after treatment. Results: there was no significant difference in the levels of NOIL-1TNF- 伪 between the two groups before treatment. After treatment, the levels of NOIL-1TNF- 伪 in the two groups were significantly lower than those in the same group, and the levels of TNF- 伪 in the observation group were significantly lower than those in the control group. The mortality, sequelae and adverse reactions in the observation group were significantly lower than those in the control group. Conclusion: mannitol combined with dexamethasone can reduce the levels of inflammatory factors, sequelae and mortality in patients with infective brain edema, and does not increase the incidence of adverse reactions.
【作者单位】： 南阳市中心医院/郑州大学附属南阳医院感染性疾病科;南阳医学高等专科学校基础医学部;
【分类号】：R742
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本文编号：1666176