脑小血管病患者肾小球滤过率和微量白蛋白检测与认知功能的关系

发布时间：2018-03-27 14:16

  本文选题：脑小血管病　切入点：肾小球滤过率　出处：《中国现代医学杂志》2017年14期

【摘要】：目的 探讨脑小血管病(CSVD)患者的肾小球滤过率(GFR)和尿微量白蛋白(m ALB)水平与认知损害的关系。方法 选取84例CSVD患者(CSVD组)和50例健康体检者(对照组)为研究对象,测定患者的生化指标和m ALB,计算GFR,分析GFR和m ALB与认知损害的相关性。结果 CSVD组的GFR、尿微量白蛋白阳性率与对照组比较,差异无统计学意义(P0.05),CSVD组的GFR水平低于对照组,尿微量白蛋白水平则高于对照组;CSVD患者GFR阳性组的Mo CA评分低于GFR阴性组,合并VCI发生率则高于GFR阴性组;CSVD患者尿微量白蛋白阳性组的Mo CA评分低于尿微量白蛋白阴性组,合并VCI发生率则高于尿微量白蛋白阴性组。结论 CSVD合并GFR及m ALB水平异常的患者均存在不同程度认知功能障碍,GFR及m ALB水平异常可能参与CSVD认知功能损害的发病过程,GFR和m ALB的检测对于CSVD合并认知功能损害的早期筛查具有重要意义。
[Abstract]:Objective to investigate the relationship between glomerular filtration rate (GFR) and urinary albumin (Alb) levels and cognitive impairment in patients with small cerebral vascular disease (CSVD). Methods 84 patients with CSVD and 50 healthy controls were selected as subjects. The correlation between GFR and m ALB and cognitive impairment was analyzed. Results compared with the control group, the positive rate of urinary microalbumin in the CSVD group was lower than that in the control group, and the GFR level in the CSVD group was lower than that in the control group. The level of urinary microalbumin was higher in GFR positive group than that in GFR negative group, and the incidence of VCI was higher in GFR negative group than that in GFR negative group. The incidence of VCI in patients with VCI was higher than that in patients with negative urinary microalbumin.Conclusion the abnormal levels of GFR and m ALB in patients with CSVD and abnormal GFR and m ALB levels may be involved in the development of cognitive impairment of CSVD. The detection of GFR and m ALB plays an important role in the early screening of CSVD with cognitive impairment.
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