脑脊液和血清中PCT与NSE及CRP检测在颅内感染诊断中的价值分析

发布时间：2018-03-28 05:30

本文选题：脑脊液　切入点：血清　出处：《中华医院感染学杂志》2017年11期

【摘要】：目的观察颅内感染患者脑脊液和血清中降钙素原(PCT)、神经元特异性烯醇化酶(NSE)、C-反应蛋白(CRP)的表达特点,初步分析检测血清PCT、NSE、CRP对颅内感染的诊治价值。方法选取2012年4月-2015年10月在医院行开颅手术后并发颅内感染的90例患者为观察组,将无颅内感染、资料相匹配的30例患者为对照组,对比分析两组患者血清和脑脊液PCT、NSE、CRP的表达特征。结果颅内感染各组患者的血清和脑脊液PCT、NSE、CRP水平显著高于对照组,且化脓性组患者PCT、CRP水平显著高于其他两组感染患者,而病毒性组NSE水平显著高于其他两组感染患者,各组间检测结果差异有统计学意义(P0.05);颅内感染昏迷组患者PCT、NSE和CRP水平均显著高于对照组和未昏迷组,且未昏迷组上述指标显著高于对照组,各组间PCT、NSE和CRP表达差异有统计学意义(P0.05)。结论脑脊液和血清PCT、NSE、CRP表达水平在一定程度上能够反应颅内感染的病情严重程度,对于颅内感染鉴别诊断和病情评估具有参考价值。
[Abstract]:Objective to observe the expression of procalcitonin (PCT) and neuron specific enolase (NSE) in cerebrospinal fluid (CSF) and serum of patients with intracranial infection. Methods 90 patients with intracranial infection after craniotomy from April 2012 to October 2015 were selected as the observation group. Data 30 matched patients as control group, the expression characteristics of PCTnSE-CRP in serum and cerebrospinal fluid of two groups were analyzed. Results the levels of PCTnSE-CRP in serum and cerebrospinal fluid of patients with intracranial infection were significantly higher than those in control group. The level of NSE in suppurative group was significantly higher than that in other two groups, but the level of NSE in viral group was significantly higher than that in other two groups. The levels of CRP and CRP in the patients with intracranial infection coma were significantly higher than those in the control group and the non-coma group, and the above indexes in the uncomatose group were significantly higher than those in the control group. Conclusion the expression of CRP in cerebrospinal fluid and serum can reflect the severity of intracranial infection to a certain extent, and has reference value for differential diagnosis and evaluation of intracranial infection.
【作者单位】：南阳市中心医院神经外科;
【分类号】：R742.9

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