盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果

发布时间：2018-03-28 21:48

本文选题：新生儿　切入点：缺氧缺血性脑病　出处：《中国医学创新》2016年36期

【摘要】：目的:探讨盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果。方法:选取2012年10月-2015年11月本院确诊治疗的缺氧缺血性脑病患儿100例,依据随机分配原则分为美芬蛋白组和美芬组,每组50例。美芬组患儿给予常规基础治疗及盐酸纳美芬治疗,美芬蛋白组患儿在此基础上给予曲克芦丁脑蛋白水解物注射液治疗,采用神经行为测定(NBNA)评分评估患儿的神经功能,采用Gesell发育量表评估患儿智能发育情况,并统计分析患儿的临床疗效和不良反应发生情况。结果:美芬蛋白组患儿治疗总有效率、NBNA评分及DQ均明显高于美芬组,差异均有统计学意义(P0.05);美芬蛋白组和美芬组患儿不良反应发生率分别为16.00%、6.00%,两组比较差异无统计学意义(P0.05)。结论:盐酸纳美芬联合曲克芦丁脑蛋白水解物注射液治疗可有效缓解新生儿缺氧缺血性脑病的临床症状,提高患儿的临床疗效,且具有良好的安全性,值得临床作进一步推广。
[Abstract]:Objective: to investigate the clinical effect of namefen hydrochloride combined with troxorutin protein hydrolysate injection in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: from October 2012 to November 2015, 100 patients with HIE were selected. According to the principle of random distribution, the children in the mefen group were divided into mefen group and mefen group with 50 cases in each group. The children in the mefen group were treated with routine basic treatment and nalmefen hydrochloride, and the children in the mefen group were treated with troxerutin brain protein hydrolysate injection. The neurological function of children was evaluated by neurobehavioral test, and the intelligence development of children was evaluated by Gesell developmental scale. Results: the total effective rate and DQ of mefen protein group were significantly higher than that of mefen group. The incidence of adverse reactions in mefen protein group and mefen group was 16.00 ~ 6.00, respectively. There was no significant difference between the two groups (P 0.05). Conclusion: namefen hydrochloride combined with troxerutin brain protein hydrolysate injection is effective. It can effectively relieve the clinical symptoms of neonatal hypoxic-ischemic encephalopathy. Improve the clinical efficacy of children, and have good safety, worthy of further clinical promotion.
【作者单位】：江西省丰城市人民医院;
【分类号】：R742

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