帕金森病伴发焦虑的相关因素研究

发布时间：2018-03-30 09:13

本文选题：焦虑　切入点：帕金森病　出处：《武汉大学学报(医学版)》2016年03期

【摘要】：目的:探讨帕金森病(PD)伴发焦虑的相关因素。方法:采用贝克焦虑量表(BAI)将入组60例PD患者分为焦虑和非焦虑组。记录两组患者基本情况及用药情况。选用帕金森病统一评价量表(UPDRS)和改良HoehnYahr(HY)分期评价患者运动症状;选用蒙特利尔认知评估量表(MOCA)、贝克抑郁量表(BDI)、PD睡眠量表(PDSS)、Epworth嗜睡量表(ESS)和PD自主神经症状量表(SCOPA-AUT)评价患者非运动症状。结果:基本情况及运动症状方面,焦虑组与非焦虑组间差异无统计学意义。PD药物使用方面,焦虑组金刚烷胺的日剂量及左旋多巴等效日剂量(LEDD)低于非焦虑组(P0.05)。非运动症状方面,焦虑组BDI、PDSS和SCOPA-AUT得分高于非焦虑组(P0.05)。回归分析示,BAI得分与BDI、SCOPA-AUT得分呈正相关,与LEDD呈负相关。结论:抑郁和自主神经功能障碍是PD焦虑的危险因素,LEDD是PD焦虑的保护因素。
[Abstract]:Objective: to investigate the related factors of anxiety associated with Parkinson's disease (PD). Methods: 60 patients with PD were divided into anxiety group and non-anxiety group by using Baker anxiety scale (BAI). The basic condition and medication of the two groups were recorded. Parkin was selected. The patients' motor symptoms were evaluated by UPDRSs and modified HoehnYahr-HYS (modified HoehnYahr-HYS). The Montreal Cognitive Assessment scale (MOCAA), Baker Depression scale (BDI), Epworth sleepiness scale (ESSS) and PD autonomic nervous symptom scale (SCOPA-AUTT) were used to evaluate the patients' non-motor symptoms. There was no significant difference between anxiety group and non-anxiety group. The daily dose of amantadine and the equivalent daily dose of levodopa in anxiety group were lower than those in non-anxiety group (P 0.05). The scores of BDII-PDSS and SCOPA-AUT in anxiety group were higher than those in non-anxiety group (P 0.05). The regression analysis showed that the score of Bai was positively correlated with the score of BDII-SCOPA-AUT and negatively correlated with LEDD. Conclusion: depression and autonomic dysfunction are the risk factors of PD anxiety and LeDD is the protective factor of PD anxiety.
【作者单位】：武汉大学人民医院神经内科;
【基金】：湖北省卫计委重点项目(编号:WJ2015MA007) 武汉市科技局2015年应用基础研究计划项目(编号:2015060101010047)
【分类号】：R742.5;R749.72

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