运动神经元病患者脑白质病变的扩散张量成像研究

发布时间：2018-04-01 17:01

  本文选题：运动神经元病　切入点：扩散张量成像　出处：《华中科技大学学报(医学版)》2017年06期

【摘要】：目的利用扩散张量成像技术(DTI)定量评估运动神经元病患者的脑白质病变,探究可能的发病机制。方法15例临床诊断为运动神经元病患者作为实验组,16例年龄、性别匹配的无神经系统疾病的志愿者为对照组。行DTI及常规磁共振扫描,应用基于纤维束的空间统计方法(TBSS)对全脑白质进行分析,提取异常区域的部分各项异性(FA值)、平均弥散率(MD值)、特征值(λ1、λ2、λ3)。结果实验组与对照组相比,左侧皮质脊髓束FA值显著下降(P=0.034),特征值λ2(P=0.124)、λ3(P=0.064)有升高趋势,右侧皮质脊髓束FA值有下降趋势(P=0.050)。两组λ1、MD值未见明显差异。结论 DTI能够定量显示运动神经元病患者皮质脊髓束损害,并且该病变可能是脱髓鞘所致。
[Abstract]:Objective using diffusion tensor imaging (DTI) quantitative assessment of cerebral white matter lesions in patients with motor neuron disease, to explore the possible pathogenesis. Methods 15 patients with motor neuron disease patients as the experimental group, 16 cases of age, gender, without neurological diseases volunteers as control group underwent DTI and conventional. Magnetic resonance imaging, the application of statistical method based on fiber bundle space (TBSS) on cerebral white matter analysis, extraction of anisotropic abnormal area part (FA), average diffusion rate (MD value), eigenvalue (lambda 1, lambda 2, lambda 3). The results of the experimental group compared with the control group on the left side of the corticospinal tract FA value decreased significantly (P=0.034), (P=0.124) eigenvalue lambda 2, lambda 3 (P=0.064) increased, on the right side of the corticospinal tract FA value decreased (P=0.050). Two groups of lambda 1, there was no significant difference between the values of MD. Conclusion DTI can quantitatively show the corticospinal motor neuron disease beam Damage, and the lesion may be caused by demyelination.

【作者单位】： 浙江省中医药大学附属第一医院神经内科;华中科技大学同济医学院附属协和医院神经内科;
【分类号】：R445.2;R744.8
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本文编号：1696447