高收缩压轨迹是脑出血的危险因素

发布时间：2018-04-01 22:19

本文选题：收缩压轨迹　切入点：脑出血　出处：《中华高血压杂志》2017年06期

【摘要】：目的探讨不同的收缩压轨迹对脑出血的影响。方法以参加2006-2007、2008-2009和2010-2011年3次健康体检的开滦研究人群作为研究队列,其中符合入选标准的研究对象共55 194人。收缩压轨迹通过SAS Proc Traj程序确定;采用寿命表法计算不同收缩压轨迹组脑出血的累积发生率,并用Log-rank检验比较不同收缩压轨迹组脑出血累积发生率的差异;采用Cox比例风险模型分析不同收缩压轨迹组对脑出血的影响。结果纳入统计分析的研究对象55 194人通过SAS Proc Traj程序确定了5组不同的收缩压轨迹:低-稳定组、正常-稳定组、中-高组、高-中组和高-稳定组。平均随访(4.99±0.39)年,共发生脑出血164例。低-稳定组、正常-稳定组、中-高组、高-中组和高-稳定组脑出血的累积发生率分别为0.05%、0.20%、0.80%、0.60%和0.80%(P0.01)。多因素Cox回归分析显示,在校正多种混杂因素后,与低-稳定组相比,正常-稳定组、中-高组、高-中组和高-稳定组脑出血的发生风险均增加,其HR(95%CI)分别为3.48(1.41~8.56)、15.01(5.67~39.71)、11.47(3.70~35.61)和18.40(5.28~64.14)。结论高收缩压轨迹是发生脑出血的独立危险因素。
[Abstract]:Objective to investigate the effect of different systolic blood pressure trajectories on intracerebral hemorrhage.Methods A total of 55,194 subjects were enrolled in the Kailuan study, who participated in three health checkups from 2006 to 2007, 2008-2009 and 2010-2011, among which 55,194 subjects met the inclusion criteria.The systolic blood pressure trajectory was determined by SAS Proc Traj program, the cumulative incidence of cerebral hemorrhage in different systolic blood pressure loci was calculated by life table method, and the difference of cumulative incidence rate of cerebral hemorrhage in different systolic blood pressure trajectories was compared with Log-rank test.Cox proportional risk model was used to analyze the effects of different systolic blood pressure trajectories on cerebral hemorrhage.Results SAS Proc Traj program was used to determine five different systolic blood pressure trajectories: low stable group, normal stable group, middle high group, high middle group and high stable group.The mean follow-up time was 4.99 卤0.39 years, 164 cases of intracerebral hemorrhage occurred.The cumulative incidence of intracerebral hemorrhage in low stable group, normal stable group, middle high group, high medium group and high stable group was 0. 05% and 0. 20%, 0.80% and 0. 80% respectively.Conclusion High systolic blood pressure is an independent risk factor for intracerebral hemorrhage.
【作者单位】：开滦总医院心内科;华北理工大学研究生院;首都医科大学附属北京天坛医院神经临床试验与临床研究中心;
【分类号】：R743.34

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