急性脑梗死患者重组组织型纤溶酶原激活剂静脉溶栓后出血性转化的危险因素分析

发布时间：2018-04-02 19:50

  本文选题：脑梗死　切入点：静脉溶栓　出处：《中国医科大学学报》2017年12期

【摘要】：目的探讨急性脑梗死患者静脉输注重组组织型纤溶酶原激活剂(rt-PA)后出血性转化的相关危险因素。方法采用病例-对照研究的方法,选取21例急性脑梗死接受rt-PA静脉溶栓治疗后出现脑出血性转化者为病例组,并选择同一时期63例急性脑梗死接受rt-PA静脉溶栓治疗后未发生脑出血性转化者为对照组。应用单因素及多因素logistic回归分析溶栓后出血性转化的相关危险因素。结果单因素分析结果显示,病例组中溶栓前美国国立卫生院卒中量表(NIHSS)评分10分、高血压(溶栓前收缩压≥140 mmHg)、溶栓前血糖值升高、具有心房颤动史和脑血管疾病史的比例显著高于对照组。多因素logistic回归分析结果显示,溶栓前收缩压≥140 mmHg(OR=14.59,95%CI:1.63~130.95)、溶栓前血糖值升高(OR=9.92,95%CI:0.97~101.24)以及具有脑血管疾病史(OR=10.75,95%CI:1.76~65.78)是急性脑梗死患者接受rt-PA静脉溶栓后出血性转化的危险因素。结论溶栓前收缩压≥140 mmHg、溶栓前血糖值升高以及具有脑血管疾病史是急性脑梗死患者接受rt-PA静脉溶栓后出血性转化的危险因素。
[Abstract]:Objective to investigate the risk factors of hemorrhagic transformation after intravenous infusion of recombinant tissue plasminogen activator (rt-PA) in patients with acute cerebral infarction.Methods A case-control study was conducted in 21 patients with acute cerebral infarction who underwent intravenous thrombolytic therapy with rt-PA.63 patients with acute cerebral infarction received intravenous thrombolytic therapy with rt-PA were selected as control group.Univariate and multivariate logistic regression analysis was used to analyze the risk factors of hemorrhagic transformation after thrombolysis.Results the results of univariate analysis showed that the stroke scale of the National Institutes of Health before thrombolysis was 10 points, hypertension (systolic pressure before thrombolysis 鈮，

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