尤瑞克林联合曲克芦丁脑蛋白水解物对急性脑梗死患者凝血功能及神经功能的影响

发布时间：2018-04-08 14:41

本文选题：尤瑞克林　切入点：曲克芦丁脑蛋白水解物　出处：《实用临床医药杂志》2016年09期

【摘要】：目的探讨尤瑞克林联合曲克芦丁脑蛋白水解物对急性脑梗死患者凝血功能及神经功能的影响。方法将96例急性脑梗死患者随机分为治疗组和对照组,各48例。对照组给予尤瑞克林治疗,治疗组在此基础上加用曲克芦丁脑蛋白水解物注射液。观察2组临床疗效,比较治疗前后凝血功能指标及神经细胞因子水平,并对神经功能缺损程度进行评估。结果治疗组总有效率显著高于对照组(91.67%vs.77.08%,P0.05)。治疗后,2组纤维蛋白原、D-二聚体(D-D)水平及血小板计数均较治疗前显著降低(P0.05或P0.01),治疗组上述指标显著低于对照组(P0.01)。治疗后,2组神经营养因子(NTF)、神经生长因子(NGF)水平显著升高(P0.01),神经元特异性烯醇化酶(NSE)水平显著降低(P0.01),其中治疗组升高及降低程度显著大于对照组(P0.01)。治疗后1、3、5、7、14 d,2组NIHSS评分依次降低(P0.01);治疗组治疗后各时间点NIHSS评分显著低于对照组(P0.01)。结论尤瑞克林联合曲克芦丁脑蛋白水解物能有效改善急性脑梗死患者的凝血功能和神经功能。
[Abstract]:Objective to investigate the effects of eurexine combined with troxorutin hydrolysate on blood coagulation and nerve function in patients with acute cerebral infarction.Methods 96 patients with acute cerebral infarction were randomly divided into treatment group (n = 48) and control group (n = 48).The control group was treated with eucrine, and the treatment group was treated with troxorutin brain protein hydrolysate injection.To observe the clinical effect of the two groups, to compare the coagulation function index and nerve cell factor level before and after treatment, and to evaluate the degree of nerve function defect.Results the total effective rate in the treatment group was significantly higher than that in the control group (91.67 vs 77.08).After treatment, the levels of fibrinogen D-D and platelet count in both groups were significantly lower than those before treatment (P 0.05 or P 0.01), and the above indexes in the treatment group were significantly lower than those in the control group (P 0.01).After treatment, the levels of neurotrophic factor NTFN, NGF, NGF and NSEs were significantly increased in both groups, and the level of neuron specific enolase (NSE) was significantly decreased in the treatment group than that in the control group (P 0.01), and the increase and decrease in the treatment group were significantly higher than that in the control group (P 0.01).After treatment, the NIHSS score of the two groups was significantly lower than that of the control group (P 0.01), and that of the treatment group was significantly lower than that of the control group (P 0.01) at each time point.Conclusion Urethrin combined with troxorutin can effectively improve the blood coagulation function and nerve function in patients with acute cerebral infarction.
【作者单位】：辽宁省锦州市中心医院神经内科;
【基金】：中国高校医学期刊临床专项资金(11524326)
【分类号】：R743.3

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