老年脑梗死患者血浆中B型脑钠肽的变化特征及其临床意义

发布时间：2018-04-09 09:25

  本文选题：老年　切入点：脑梗死　出处：《老年医学与保健》2016年06期

【摘要】：目的 观察老年脑梗死(cerebral infarction,CI)患者血浆中B型脑钠肽(brain natriuretic peptide,BNP)水平的变化特征,探讨BNP在CI中的临床应用意义。方法 选择60例老年CI患者为观察组,58名体检健康者为对照组;60例CI患者依据病程将CI分为急性期(发病3d内)亚组和亚急性期(发病3~10 d)亚组;60例CI患者根据头颅MRI分型将脑梗死为大面积脑梗死(病灶直径5 cm)亚组和非大面积脑梗死(病灶直径≤5 cm)亚组。检测各组和亚组血浆中的BNP水平与进行比较分析。结果 CI组血浆BNP水平显著高于对照组(P0.01);CI组急性期亚组血浆BNP含量明显高于对照组(P0.01),也显著高于亚急性期亚组(P0.01);大面积CI亚组血浆BNP含量显著高于非大面积CI亚组(P0.01)。结论 急性期和大面积CI老年患者血浆BNP水平明显升高,提示BNP可能在老年CI发生过程中起着重要作用,可望成为CI诊断指标。
[Abstract]:Objective to observe the changes of plasma levels of type B brain natriuretic peptide (natriuretic) in elderly patients with cerebral infarction (CI) and to explore the clinical significance of BNP in CI.Methods 60 patients with CI were divided into acute stage (within 3 days) group and subacute phase (3 to 10 days) subgroup according to the course of disease. According to the course of disease, 60 patients with CI were divided into two groups: the control group (n = 58) and the control group (n = 58).According to MRI classification, cerebral infarction was subdivided into subgroup of large area cerebral infarction (lesion diameter 5 cm) and non large area cerebral infarction (lesion diameter 鈮，

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