红细胞分布宽度与脑白质病变严重程度的相关性

发布时间：2018-04-10 05:26

本文选题：红细胞分布宽度　切入点：脑白质病变　出处：《广东医学》2017年22期

【摘要】：目的探讨红细胞分布宽度(RDW)与脑白质病变严重程度的相关性。方法收集头颅MRI证实脑白质病变患者,回顾性分析患者的临床资料及危险因素。结果 (1)本研究共纳入409例脑白质病变患者,根据Fezakas量表评分分成轻度者(n=266)和中重度者(n=143)。(2)单因素分析示:轻度与中重度者两组间比较年龄、高血压、红细胞计数、血红蛋白、RDW标准差(RDW-SD)、RDW变异系数(RDW-CV)、纤维蛋白原、肌酐、总胆固醇、同型半胱氨酸差异有统计学意义(P0.05)。(3)多因素logistic回归分析示RDW-CV作连续型变量资料时,调整混杂因素后发现年龄(OR=1.158,95%CI 1.122~1.195,P0.001)、高血压(OR=2.103,95%CI 1.254~3.526,P=0.005)、RDW-CV(OR=1.308,95%CI 1.062~1.610,P=0.011)是中重度脑白质病变的独立危险因素。(4)RDW-CV与中重度脑白质病变的受试者工作曲线,曲线下面积为0.643(95%CI 0.587~0.699,P0.001),当约登指数最大时,RDW-CV最佳截断值为13.05%,其对中重度脑白质病变预测敏感度为51.0%,特异度为74.1%。结论在脑白质病变患者中,年龄、高血压、RDW-CV是中重度脑白质病变的独立危险因素,高水平RDW-CV对中重度脑白质病变有一定的预测价值。
[Abstract]:Objective to investigate the correlation between RDW and the severity of white matter lesions.Methods the clinical data and risk factors of white matter lesions confirmed by MRI were analyzed retrospectively.Results 1) A total of 409 patients with leukoencephalopathy were enrolled in this study. According to the Fezakas scale, they were divided into mild patients (n = 266) and moderate and severe patients (n = 143). Univariate analysis showed that age, hypertension, red blood cell count were compared between mild and moderate severe patients.The coefficient of variation of RDW-CVG, fibrinogen, creatinine, total cholesterol and homocysteine were significantly different between RDW-SDW standard deviation and RDW-SDW standard deviation of hemoglobin. The multivariate logistic regression analysis showed that RDW-CV was used as the continuous variable data, and there were significant differences in RDW-CVG, fibrinogen, creatinine, total cholesterol and homocysteine between RDW and RDW standard deviation (P < 0.05).The area under the curve was 0.643(95%CI 0.587U 0.699g P0.001g. The best truncation value of RDW-CV was 13.05 when the Yorden index was the largest. The sensitivity and specificity of RDW-CV were 51.0 and 74.1 for moderate and severe white matter lesions.Conclusion Age and hypertension RDW-CV are independent risk factors for moderate and severe white matter lesions in patients with leukoencephalopathy. High level of RDW-CV may be a predictor of moderate and severe white matter lesions.
【作者单位】：南方医科大学第三附属医院神经内科;
【基金】：国家自然科学基金资助项目(编号:81500986) 广东省自然科学基金资助项目(编号:2014A030313273)
【分类号】：R742

【相似文献】