不同剂量低分子肝素对急性脑梗死的疗效研究

发布时间：2018-04-10 18:30

本文选题：脑梗死 + 低分子肝素　；参考：《临床医学研究与实践》2016年21期

【摘要】：目的研究不同剂量低分子肝素对急性脑梗死的治疗效果。方法选择2015年1月至2015年12月在我院进行诊治的急性脑梗死患者120例,随机分为对照组、小剂量组和大剂量组,各40例。对照组给予血栓通,小剂量组给予低分子肝素4 100抗-Xa IU,1次/d,大剂量组给予低分子肝素4 100抗-Xa IU,2次/d,观察三组的疗效。结果大剂量组的总有效率为80.00%,明显高于对照组的60.00%和小剂量组的72.50%(P0.05);治疗后,三组的NIHSS评分均明显降低(P0.05),Barthel指数均明显升高(P0.05),且与小剂量组、对照组相比,大剂量组的NIHSS评分降低更明显(P0.05),Barthel指数升高也更明显(P0.05);三组的梗死灶体积均明显降低(P0.05),且大剂量组降低的更为明显(P0.05)。结论不同剂量的低分子肝素均能改善急性脑梗死患者的神经功能,尤其是大剂量低分子肝素疗效更好。
[Abstract]:Objective to study the therapeutic effect of low molecular weight heparin (LMWH) on acute cerebral infarction (ACI).Methods 120 patients with acute cerebral infarction who were treated in our hospital from January 2015 to December 2015 were randomly divided into control group, small dose group and high dose group, 40 cases each.The control group was given Xueshuantong, the low dose group was given low molecular heparin 4 100 anti Xa IUU once a day, the large dose group was given low molecular heparin 4 100 anti Xa IUU for 2 times per day, and the curative effect was observed in the three groups.Results the total effective rate of the high dose group was 80.00g, which was significantly higher than that of the control group (60.00%) and the small dose group (72.50%). After treatment, the NIHSS scores of the three groups were significantly lower than that of the low dose group and the control group.The NIHSS score in the high dose group was significantly lower than that in the high dose group (P 0.05), and the infarct volume in the three groups was significantly lower than that in the high dose group (P 0.05), and that in the high dose group was significantly lower than that in the high dose group (P 0.05).Conclusion different doses of low molecular weight heparin can improve neurological function in patients with acute cerebral infarction, especially high dose low molecular weight heparin.
【作者单位】：陕西汉中勉县九冶医院神经内科;
【分类号】：R743.33

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