颅内椎基底动脉狭窄患者血清和肽素水平的变化及其与支架成形术后再狭窄的相关因素分析

发布时间：2018-04-11 07:28

本文选题：和肽素 + 颅内椎基底动脉狭窄　；参考：《广西医科大学学报》2016年06期

【摘要】：目的:探讨颅内椎基底动脉狭窄患者血清和肽素水平的变化及其与支架成形术后再狭窄的相关因素分析。方法:选取130例颅内椎基底动脉狭窄并行支架成形术患者,随访1年,依据其是否再次发生颅内椎基底动脉狭窄分为再狭窄组(n=28)和无狭窄组(n=102)。比较两组血清和肽素水平,并分析血清和肽素与血管再狭窄的关系。结果:术前、术后3d及术后1年,再狭窄组血清和肽素水平分别为(19.6±4.2)pmol/L、(25.8±6.4)pmol/L、(20.4±3.9)pmol/L,无狭窄组分别为(19.2±3.5)pmol/L、(25.1±7.3)pmol/L、(12.8±2.6)pmol/L。术前及术后3d,两组患者血清和肽素水平比较差异无统计学意义(P0.05);术后1年,再狭窄组血清和肽素水平明显高于无狭窄组(P0.05)。多因素Logistic回归分析结果显示,和肽素是颅内椎基底动脉支架成形术再狭窄的独立危险因素(OR=4.405,95%CI:1.121~8.327,P0.05)。结论:血清和肽素是预测颅内椎基底动脉狭窄支架成形术再狭窄的可靠血清学指标。
[Abstract]:Objective: to investigate the changes of serum and peptide levels in patients with intracranial vertebrobasilar artery stenosis and their correlation with restenosis after stent angioplasty.Methods: 130 patients with intracranial vertebrobasilar artery stenosis and stent angioplasty were followed up for one year. According to whether intracranial vertebrobasilar artery stenosis occurred again, they were divided into restenosis group (n = 130) and no stenosis group (n = 102).Serum and peptide levels were compared and the relationship between serum and peptide levels and vascular restenosis was analyzed.There was no significant difference in serum and peptide levels between the two groups before operation and 3 days after operation, but the levels of serum and peptide in restenosis group were significantly higher than those in non-stenosis group (P 0.05) one year after operation.Multivariate Logistic regression analysis showed that peptide was an independent risk factor for restenosis of intracranial vertebrobasilar artery stenting and restenosis.Conclusion: serum and peptide are reliable serological markers for predicting stenting restenosis in intracranial vertebrobasilar artery stenosis.
【作者单位】：广西医科大学附属民族医院神经内科;
【分类号】：R743.3

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